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Titolo:
SYNTAXIN-11 - A MEMBER OF THE SYNTAXIN FAMILY WITHOUT A CARBOXYL-TERMINAL TRANSMEMBRANE DOMAIN
Autore:
TANG BL; LOW DYH; HONG WJ;
Indirizzi:
NATL UNIV SINGAPORE,INST MOL & CELL BIOL,MEMBRANE BIOL LAB,30 MED DR SINGAPORE 117609 SINGAPORE NATL UNIV SINGAPORE,INST MOL & CELL BIOL,MEMBRANE BIOL LAB SINGAPORE 117609 SINGAPORE
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 2, volume: 245, anno: 1998,
pagine: 627 - 632
SICI:
0006-291X(1998)245:2<627:S-AMOT>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN; TRANSPORT; DOCKING; RECEPTORS; VESICLES; FUSION; CELLS;
Keywords:
SYNTAXIN; TAIL ANCHOR; PROTEIN TRANSPORT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
B.L. Tang et al., "SYNTAXIN-11 - A MEMBER OF THE SYNTAXIN FAMILY WITHOUT A CARBOXYL-TERMINAL TRANSMEMBRANE DOMAIN", Biochemical and biophysical research communications, 245(2), 1998, pp. 627-632

Abstract

We have cloned a novel syntaxin-like molecule, designated human syntaxin 11 (hsyn11). The open reading frame encodes a polypeptide of 287 amino acids with potential coiled-coil domains. hysn11 has extensive homology to members of the syntaxin family, particularly syntaxin 1 and syntaxin 2. Unlike other members of the syntaxin family, however, hsyn11 has a short cysteine-rich carboxyl-terminal tail but not a typical hydrophobic domain which may serve as a membrane anchor. Northern blotanalysis revealed two transcripts of similar to 0.8 kb and similar to1.7 kb in length that are particularly abundant in heart and placenta, although lower levels were also detectable in other tissues except in the brain. Consistent with the lack of a distinct membrane anchoragesequence in hsyn11, indirect immunofluorescence microscopy of transiently expressed N-terminally myc-tagged hsyn11 revealed a diffuse, cytoplasmic labeling. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 21:08:28