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Titolo:
SUBSTANCE-P STIMULATES SPHINCTER OF ODDI MOTILITY AND INHIBITS TRANSSPHINCTERIC FLOW IN THE AUSTRALIAN BRUSH-TAILED POSSUM
Autore:
COX MR; PADBURY RTA; HARVEY JR; BAKER RA; TOOULI J; SACCONE GTP;
Indirizzi:
FLINDERS UNIV S AUSTRALIA,FLINDERS MED CTR,DEPT SURG,BEDFORD PK ADELAIDE SA 5042 AUSTRALIA FLINDERS UNIV S AUSTRALIA,FLINDERS MED CTR,DEPT SURG ADELAIDE SA 5042AUSTRALIA
Titolo Testata:
Neurogastroenterology and motility
fascicolo: 2, volume: 10, anno: 1998,
pagine: 165 - 173
SICI:
1350-1925(1998)10:2<165:SSSOOM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG GALLBLADDER; NERVE-FIBERS; CELLS; IMMUNOREACTIVITY; NEUROPEPTIDES; NEURONS; MUSCLE; CAT;
Keywords:
IMMUNOHISTOCHEMISTRY; SPHINCTER OF ODDI MOTILITY; SUBSTANCE P; TRANSSPHINCTERIC FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
M.R. Cox et al., "SUBSTANCE-P STIMULATES SPHINCTER OF ODDI MOTILITY AND INHIBITS TRANSSPHINCTERIC FLOW IN THE AUSTRALIAN BRUSH-TAILED POSSUM", Neurogastroenterology and motility, 10(2), 1998, pp. 165-173

Abstract

Substance P containing nerves are widely distributed throughout the gastrointestinal tract. The aims of this study were to determine the distribution of substance P containing nerves in the extrahepatic biliary tree of the Australian brush-tailed possum and to characterize the effect of exogenous substance P on the sphincter of Oddi (SO) motility and transsphincteric flow in vivo. Immunohistochemical staining of fixed specimens (n = 8) found moderate numbers of substance P containing nerve cell bodies and fibres throughout the neural plexuses of the SO,in particular in the serosal and intraluminal nerve trunks of the SO and gallbladder. Synthetic porcine substance P (1-2000 ng kg(-1)), administered by close intra-arterial injection (i.a.; n = 7), produced a dose-dependent elevation in basal pressure [P < 0.01] and an associated dose-dependent reduction in transsphincteric flow [P < 0.0001]. Substance P had no significant dose-dependent effect on SO phasic contraction amplitude or frequency. Tetrodotoxin (9 mu g kg(-1), i.a.) did notinhibit the effect of substance P on SO motility and trans-sphincteric flow (n = 5). in conclusion, substance P containing nerves lire found throughout the possum extrahepatic biliary tree. Exogenous substanceP stimulates SO motility and reduces trans-sphincteric flow in vivo by acting directly on the sphincter smooth muscle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 06:14:13