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Titolo:
ANTIBODIES DIRECTED AGAINST ZAP-70 CROSS-REACT WITH A 66 KDA TYROSINEKINASE IN THE RAT-BRAIN
Autore:
YONEYA H; YANAGI S; INATOME R; DING JY; HITOMI T; AMATSU M; YAMAMURA H;
Indirizzi:
KOBE UNIV,SCH MED,DEPT BIOCHEM,CHUO KU KOBE HYOGO 6500017 JAPAN KOBE UNIV,SCH MED,DEPT BIOCHEM,CHUO KU KOBE HYOGO 6500017 JAPAN KOBE UNIV,SCH MED,DEPT OTORHINOLARYNGOL,CHUO KU KOBE HYOGO 6500017 JAPAN
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 1, volume: 245, anno: 1998,
pagine: 140 - 143
SICI:
0006-291X(1998)245:1<140:ADAZCW>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL TRANSDUCTION; NEURITE OUTGROWTH; ACTIVATION; PHOSPHORYLATION; P72(SYK); MOLECULE; NEURONS; CELLS; NCAM; SYK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
H. Yoneya et al., "ANTIBODIES DIRECTED AGAINST ZAP-70 CROSS-REACT WITH A 66 KDA TYROSINEKINASE IN THE RAT-BRAIN", Biochemical and biophysical research communications, 245(1), 1998, pp. 140-143

Abstract

ZAP-70 is another member of Syk family tyrosine kinases which plays an essential role in growth, differentiation, and function of T lymphocytes. In this study, we report the specific expression of a 66 kDa tyrosine kinase that is specifically cross-reacted with anti-ZAP-70 antibodies in the developing neurons. By immunoblot and immunoprecipitationassay using various anti-ZAP-70 antibodies, a 66 kDa tyrosine kinase was detected in lysates from rat brain. During the development of rat brain, expression levels of this 66 kDa tyrosine kinase were highest around 3 weeks after birth and decreased thereafter in the adult. In addition, immunoblot analysis demonstrated that this 66 kDa tyrosine kinase was expressed almost solely in the nervous system. These results suggest that this ZAP-70-related tyrosine kinase may play an important role in growth and differentiation in the developing neurons. Our observations will provide the clue to approach the regulatory system common to neurogenesis and immune response. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 02:17:42