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Titolo:
CARDIOVASCULAR MORBIDITY IN PROTEINURIC SOUTH INDIAN NIDDM PATIENTS
Autore:
VISWANATHAN V; SNEHALATHA C; MATHAI T; JAYARAMAN M; RAMACHANDRAN A;
Indirizzi:
DIABET RES CTR,5 MAIN RD ROYAPURAM 600013 CHENNAI INDIA
Titolo Testata:
Diabetes research and clinical practice
fascicolo: 1, volume: 39, anno: 1998,
pagine: 63 - 67
SICI:
0168-8227(1998)39:1<63:CMIPSI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; CORONARY HEART-DISEASE; RISK-FACTORS; VASCULAR-DISEASE; MORTALITY; MICROALBUMINURIA; ALBUMINURIA; PREDICTOR; COHORT;
Keywords:
CARDIOVASCULAR MORBIDITY; PROTEINURIA; NIDDM; HYPERTENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
V. Viswanathan et al., "CARDIOVASCULAR MORBIDITY IN PROTEINURIC SOUTH INDIAN NIDDM PATIENTS", Diabetes research and clinical practice, 39(1), 1998, pp. 63-67

Abstract

Proteinuria is a well known risk factor for cardiovascular morbidity. There has been no report on cardiovascular morbidity in Indian NIDDM patients with proteinuria. Hence this study has been undertaken to estimate the prevalence of cardiovascular diseases (CVD) in South Indian NIDDM with proteinuria, We studied two groups of NIDDM patients with diabetes for greater than or equal to 5 years: group PR with persistentproteinuria of > 500 mg/day (n = 297) and group NPR with normoalbuminuria (albuminuria less than or equal to 30 mu g/mg creatinine) (n = 296), who reported for review during the study period. They were matchedfor age, duration of diabetes and BMI. The prevalence of cardiovascular diseases, namely myocardial infarction, the presence of ischaemic heart disease and the history of coronary bypass surgery were compared in the two groups. The prevalence of hypertension was higher among thePR than the NPR patients (56.5 vs 24.7%, chi(2) = 61.3, P < 0.001). CVD were detected in 39.2% (n = 116) of the PR and 13.2% (n = 39) of the NPR groups. (chi(2) = 54.85, P < 0.001). The risk was thus three-fold higher in the PR group. Univariate analysis showed that in the proteinuric group, the prevalence of complications was higher in association with hypertension (45.8 vs 30.2%, chi(2) = 6.82, P = 0.009). Multiple logistic regression analysis showed that the factors associated withCVD were proteinuria (odds ratio 5.03), age (OR 1.08) and BMI (OR 1.07) while sex, age at onset of diabetes, duration of diabetes, hypertension, smoking, HbA(1), serum creatinine, cholesterol and triglyceridesdid not show independent contribution. The study, highlights the highrisk conferred by macroproteinuria in Indian NIDDM patients. This risk is found to be independent of the presence of associated hypertension. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 23:04:37