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Titolo:
ANTI-IL-4 MONOCLONAL-ANTIBODY PREVENTS ANTIBIOTICS-INDUCED ACTIVE FATAL ANAPHYLAXIS
Autore:
PARK JS; CHOI IH; LEE DG; HAN SS; HA TY; LEE JH; LEE WH; PARK YM; LEE HK;
Indirizzi:
CHONBUK NATL UNIV,SCH MED,DEPT IMMUNOL CHONJU 561182 SOUTH KOREA CHONBUK NATL UNIV,SCH MED,DEPT IMMUNOL CHONJU 561182 SOUTH KOREA CHONBUK NATL UNIV,SCH MED,DEPT PATHOL CHONJU 561182 SOUTH KOREA CHONBUK NATL UNIV,SCH MED,INST MED SCI CHONJU 561182 SOUTH KOREA KOREAN RES INST CHEM TECHNOL TAEJON SOUTH KOREA PUSAN NATL UNIV,SCH MED,DEPT MICROBIOL PUSAN 609735 SOUTH KOREA
Titolo Testata:
The Journal of immunology
fascicolo: 10, volume: 158, anno: 1997,
pagine: 5002 - 5006
SICI:
0022-1767(1997)158:10<5002:AMPAAF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATORY FACTOR-I; HUMAN IGE SYNTHESIS; SYSTEMIC-ANAPHYLAXIS; MODIFIED ALLERGENS; INTERFERON-GAMMA; DEFICIENT MICE; CELL; INTERLEUKIN-4; RESPONSES; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
J.S. Park et al., "ANTI-IL-4 MONOCLONAL-ANTIBODY PREVENTS ANTIBIOTICS-INDUCED ACTIVE FATAL ANAPHYLAXIS", The Journal of immunology, 158(10), 1997, pp. 5002-5006

Abstract

We previously reported that anti-IL-4 mAb (11B11) failed to prevent protein-induced fatal murine anaphylaxis. To investigate the effect of anti-IL-4 on hapten-induced anaphylaxis, a model of murine anaphylaxisinduced by antibiotics, penicillin V (Pen V) and cephalothin (CET), was developed, and the effect of anti-IL-4 on the anaphylaxis was observed. Pen V and CET induced 100 and 70 to 90% fatal reactions, respectively, when C57BL/6 mice were sensitized i.p. with 500 mu g of antibiotic-OVA conjugate with 2 x 10(9) Bordetella pertussis and 1.0 mg of alum and challenged i.v. with 100 mu g of antibiotic-BSA conjugate 14 days later. Serum taken from mice sensitized to Pen V passively sensitized normal mice to develop systemic anaphylaxis, and this ability of theserum was abrogated by heating at 56 degrees C for 2 h or depletion of IgE, but not IgG, Abs. Thus, the antibiotic-induced fatal reaction was an IgE-dependent anaphylactic reaction. Administration of anti-IL-4at the beginning of sensitization completely prevented the fatal anaphylactic reactions to both Pen V and CET. This effect of anti-IL-4 wasassociated with its suppressive activity on antibiotic-specific serumIgE, but not IgG, levels. More importantly, anti-IL-4 therapy in previously sensitized mice was also effective in preventing the fatal reactions and rapidly reduced the established IgE levels. This study provides a new animal model of hapten-induced anaphylaxis and indicates that blocking of IL-4 activity may be beneficial in allergic diseases caused by a variety of haptens in which IgE Abs play a major role.

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Documento generato il 27/01/21 alle ore 02:43:34