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Titolo:
NOVEL ANTIINFLAMMATORY COMPOUNDS INDUCE SHEDDING OF L-SELECTIN AND BLOCK PRIMARY CAPTURE OF NEUTROPHILS UNDER FLOW CONDITIONS
Autore:
ENDEMANN G; ABE Y; BRYANT CM; FENG Y; SMITH CW; LIU DY;
Indirizzi:
SCIOS NOVA INC,820 W MAUDE AVE SUNNYVALE CA 94086 BAYLOR COLL MED,DEPT PEDIAT,SECT LEUKOCYTE BIOL HOUSTON TX 77030
Titolo Testata:
The Journal of immunology
fascicolo: 10, volume: 158, anno: 1997,
pagine: 4879 - 4885
SICI:
0022-1767(1997)158:10<4879:NACISO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NODE HOMING RECEPTOR; CHEMOTACTIC FACTORS; ADHESION MOLECULE; SIALOMUCIN CD34; LUNG INJURY; IN-VITRO; NPC-15669; RECRUITMENT; INVIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
G. Endemann et al., "NOVEL ANTIINFLAMMATORY COMPOUNDS INDUCE SHEDDING OF L-SELECTIN AND BLOCK PRIMARY CAPTURE OF NEUTROPHILS UNDER FLOW CONDITIONS", The Journal of immunology, 158(10), 1997, pp. 4879-4885

Abstract

Leumedins are small molecules that inhibit neutrophil movement into inflamed tissues. These compounds have been shown to inhibit the adherence of neutrophils in static adhesion assays mediated by beta(2)-integrins. We now report that leumedins, like activating agents, induce theloss of L-selectin from the neutrophil surface. The loss of L-selectin is unrelated to the inhibition of static adhesion, since neutrophilsthat have been pretreated with leumedins to cause shedding of L-selectin, followed by removal of drug, adhere normally in a static adhesionassay, and this adhesion is inhibited upon readdition of leumedin. Inan assay of adhesion to endothelial cells under conditions of physiologic wall shear stress, leumedins prevent both primary capture of neutrophils mediated by L-selectin and firm adherence mediated by beta(2)-integrins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 23:28:02