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Titolo:
3-DIMENSIONAL P-31 MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING OF REGIONAL HIGH-ENERGY PHOSPHATE-METABOLISM IN INJURED RAT-HEART
Autore:
VONKIENLIN M; ROSCH C; LEFUR Y; BEHR W; RODER F; HAASE A; HORN M; ILLING B; HU K; ERTL G; NEUBAUER S;
Indirizzi:
UNIV WURZBURG,INST PHYS,DEPT PHYS,AM HUBLAND D-97074 WURZBURG GERMANY UNIV WURZBURG,DEPT MED D-97074 WURZBURG GERMANY
Titolo Testata:
Magnetic resonance in medicine
fascicolo: 5, volume: 39, anno: 1998,
pagine: 731 - 741
SICI:
0740-3194(1998)39:5<731:3PMSIO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYOCARDIAL-INFARCTION; CREATINE-KINASE REACTION; CORONARY-ARTERY DISEASE; NMR; LOCALIZATION; DEPLETION; RESERVE; TISSUE;
Keywords:
ISOLATED RAT HEART; MYOCARDIAL ISCHEMIA; P-31 MAGNETIC RESONANCE SPECTROSCOPIC IMAGING; INFARCT SIZE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
M. Vonkienlin et al., "3-DIMENSIONAL P-31 MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING OF REGIONAL HIGH-ENERGY PHOSPHATE-METABOLISM IN INJURED RAT-HEART", Magnetic resonance in medicine, 39(5), 1998, pp. 731-741

Abstract

The purpose of this study was to measure the spatially varying P-31 MR signals in global and regional ischemic injury in the isolated, perfused rat heart. Chronic myocardial infarcts were induced by occluding the left anterior descending coronary artery eight weeks before the MRexamination. The effects of acute global low-flow ischemia were observed by reducing the perfusate flow. Chemical shift imaging (CSI) with three spatial dimensions was used to obtain P-31 spectra in 54-mu l voxels. Multislice H-1 imaging with magnetization transfer contrast enhancement provided anatomical information. In normal hearts (n = 8), a homogeneous distribution of high-energy phosphate metabolites (HEP) wasfound. In chronic myocardial infarction (n = 6), scar tissue contained negligible amounts of HEP, but their distribution in residual myocardium was uniform. The size of the infarcted area could be measured from the metabolic images; the correlation of infarct sizes determined byhistology and P-31 MR CSI was excellent (P < 0.006). In global low-flow ischemia (n = 8), changes of HEP showed substantial regional heterogeneity. Three-dimensional P-31 MR CSI should yield new insights into the regionally distinct metabolic consequences of various forms of myocardial injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 01:51:41