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Titolo:
INHIBITION OF HUMAN COLON-CANCER CELL-GROWTH BY SELECTIVE-INHIBITION OF CYCLOOXYGENASE-2
Autore:
SHENG HM; SHAO JY; KIRKLAND SC; ISAKSON P; COFFEY RJ; MORROW J; BEAUCHAMP RD; DUBOIS RN;
Indirizzi:
VANDERBILT UNIV,MED CTR,DEPT MED GI,MCN C-2104 NASHVILLE TN 37232 VANDERBILT UNIV,MED CTR,DEPT MED NASHVILLE TN 37232 VANDERBILT UNIV,MED CTR,DEPT SURG NASHVILLE TN 37232 VANDERBILT UNIV,MED CTR,DEPT CELL BIOL NASHVILLE TN 37232 VET ADM MED CTR NASHVILLE TN 37232 SEARLE RES & DEV,DEPT INFLAMMATORY DIS RES ST LOUIS MO 63198 UNIV LONDON,ROYAL POSTGRAD MED SCH,IMPERIAL CANC RES FUND,HISTOPATHOLUNIT LONDON W12 0NN ENGLAND
Titolo Testata:
The Journal of clinical investigation
fascicolo: 9, volume: 99, anno: 1997,
pagine: 2254 - 2259
SICI:
0021-9738(1997)99:9<2254:IOHCCB>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; PROSTAGLANDIN G/H SYNTHASE-1; PROTEIN-KINASE-C; COLORECTAL-CANCER; FACTOR-ALPHA; ASPIRIN USE; DIFFERENTIAL INHIBITION; EPITHELIAL-CELLS; CARCINOMA CELLS; EXPRESSION;
Keywords:
CYCLOOXYGENASE-2; NONSTEROIDAL ANTIINFLAMMATORY DRUG; COLON CANCER; CHEMOPREVENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
H.M. Sheng et al., "INHIBITION OF HUMAN COLON-CANCER CELL-GROWTH BY SELECTIVE-INHIBITION OF CYCLOOXYGENASE-2", The Journal of clinical investigation, 99(9), 1997, pp. 2254-2259

Abstract

A considerable amount of evidence collected from several different experimental systems indicates that cyclooxygenase-2 (COX-2) may play a role in colorectal tumorigenesis. Large epidemiologic studies have shown a 40-50% reduction in mortality from colorectal cancer in persons taking aspirin or other nonsteroidal antiinflammatory drugs on a regular basis, One property shared by all of these drugs is their ability toinhibit COX, a key enzyme in the conversion of arachidonic acid to prostaglandins, Two isoforms of COX have been characterized, COX-1 and COX-2, COX-2 is expressed at high levels in intestinal tumors in humansand rodents, In this study, we selected two transformed human colon cancer cell lines for studies on the role of COX-2 in intestinal tumorigenesis. We evaluated HCA-7 cells which express high levels of COX-2 protein constitutively and HCT-116 cells which lack COX-2 protein. Treatment of nude mice implanted with HCA-7 cells with a selective COX-2 inhibitor (SC-58125), reduced tumor formation by 85-90%. SC-58125 also inhibited colony formation of cultured HCA-7 cells. Conversely, SC-58125 had no effect on HCT-116 implants in nude mice or colony formation in culture, Here we provide evidence that there may be a direct link between inhibition of intestinal cancer growth and selective inhibitionof the COX-2 pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:24:29