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Titolo:
EFFECT OF PENTYLENETETRAZOLE ON ETHANOL INTAKE, ETHANOL KINETICS, ANDSOCIAL-BEHAVIOR IN MALE WISTAR RATS
Autore:
BUCZEK Y; LE AD; SELLERS EM; TOMKINS DM;
Indirizzi:
ADDICT RES FDN,33 RUSSELL ST TORONTO ON M5S 2S1 CANADA ADDICT RES FDN TORONTO ON M5S 2S1 CANADA UNIV TORONTO,DEPT PHARMACOL TORONTO ON M5S 2S1 CANADA UNIV TORONTO,DEPT PSYCHIAT TORONTO ON M5S 2S1 CANADA UNIV TORONTO,DEPT MED TORONTO ON M5S 2S1 CANADA
Titolo Testata:
Alcoholism, clinical and experimental research
fascicolo: 2, volume: 22, anno: 1998,
pagine: 428 - 436
SICI:
0145-6008(1998)22:2<428:EOPOEI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL-PREFERRING RATS; RO15-1788 FLUMAZENIL; LABORATORY RATS; BETA-CARBOLINE; DEPRIVED RATS; PLUS-MAZE; STRESS; GABA; RO15-4513; ANXIETY;
Keywords:
ANXIETY; SOCIAL INTERACTION; ETHANOL INTAKE; PENTYLENETETRAZOLE (PTZ); ETHANOL KINETICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
67
Recensione:
Indirizzi per estratti:
Citazione:
Y. Buczek et al., "EFFECT OF PENTYLENETETRAZOLE ON ETHANOL INTAKE, ETHANOL KINETICS, ANDSOCIAL-BEHAVIOR IN MALE WISTAR RATS", Alcoholism, clinical and experimental research, 22(2), 1998, pp. 428-436

Abstract

Stress and anxiety are often implicated in excessive alcohol use, Thenature of this interaction, however, is not understood. The aim of this study was to examine the effect of the anxiogenic agent, pentylenetetrazole (PTZ), on the accquisition and maintenance of ethanol drinking behavior in male Wistar rats. In rats maintained on a limited accessprocedure, with a choice between a 12% w/v ethanol (ETOH) solution and water available for 30 min each day, acute PTZ administration (1.5 to 15.0 mg/kg) did not modify ETOH intake. Chronic PTZ administration elicited a significant suppression in ETOH intake; however, this effectdeveloped gradually over time. During the acquisition phase, chronic PTZ treatment also suppressed ETOH consumption. chronic, but not acute, treatment with PTZ seemed to enhance water consumption. To assess whether the effect of PTZ on ETOH intake was due to either alterations in ETOH kinetics or behavior, blood ETOH levels and social interaction behaviour were examined. PTZ (15.0 mg/kg) produced a significant suppression in social interaction behavior, although tolerance developed tothis effect on chronic PTZ administration. Bath acute and chronic PTZtreatment (15 mg/kg) resulted in lower blood ETOH levels achieved after administration of 1.0 g/kg po of ETOH. Because the anxiogenic effect of PTZ was not maintained on repeated administration, yet the suppression of ETOH intake was only observed after chronic treatment, this suggests a dissociation between the processes regulating these behaviors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 21:04:53