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Titolo:
IL-10 REGULATES LIVER PATHOLOGY IN ACUTE MURINE SCHISTOSOMIASIS-MANSONI BUT IS NOT REQUIRED FOR IMMUNE DOWN-MODULATION OF CHRONIC DISEASE
Autore:
WYNN TA; CHEEVER AW; WILLIAMS ME; HIENY S; CASPAR P; KUHN R; MULLER W; SHER A;
Indirizzi:
NIAID,IMMUNOL SECT,PARASIT DIS LAB,NIH,BLDG 4,ROOM 126,9000 ROCKVILLEPIKE BETHESDA MD 20892 BIOMED RES INST ROCKVILLE MD 20852 UNIV COLOGNE,GENET INST COLOGNE GERMANY
Titolo Testata:
The Journal of immunology
fascicolo: 9, volume: 160, anno: 1998,
pagine: 4473 - 4480
SICI:
0022-1767(1998)160:9<4473:IRLPIA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRANULOMA-FORMATION; CELL RESPONSES; INFECTED MICE; TH2 CYTOKINES; T-CELLS; EXPRESSION; HELMINTH; EGGS; INFLAMMATION; FIBROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T.A. Wynn et al., "IL-10 REGULATES LIVER PATHOLOGY IN ACUTE MURINE SCHISTOSOMIASIS-MANSONI BUT IS NOT REQUIRED FOR IMMUNE DOWN-MODULATION OF CHRONIC DISEASE", The Journal of immunology, 160(9), 1998, pp. 4473-4480

Abstract

We have used IL-10 gene knockout mice (IL-10T) to examine the role ofendogenous DL-IO in the down-modulation of hepatic granuloma formation and lymphocyte responses that occurs in chronic infection with the helminth parasite Schistosoma mansoni, Although IL-10-deficient animalsshowed 20 to 30% mortality between 8 and 14 wk postinfection, they displayed no alterations in their susceptibility to infection and produced similar numbers of eggs as their wild-type littermates. The IL-10T mice displayed a significant increase in hepatic granuloma size at theacute stage of infection, which was associated with increased IFN-gamma, IL-2, IL-1 beta, and TNF-alpha mRNA expression in liver and elevated Th1-type cytokine production by lymphoid cells, Despite developing an enhanced Th1-type cytokine response, the IL-10T mice showed no consistent decrease in their Th2-type cytokine profile, Surprisingly, although granulomatous inflammation was enhanced at the acute stage of infection, the livers of IL-10T mice displayed no significant increase infibrosis and underwent normal immune down-modulation at the chronic stage of infection, Moreover, the down-modulated state could be inducedin IL-10T mice by sensitizing the animals to schistosome eggs before infection, further demonstrating that the major down-regulatory mechanism is not dependent upon IL-10. We conclude that while IL-10 plays animportant role in controlling acute granulomatous inflammation, it plays no essential role in the process of immune down-modulation in chronic schistosome infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:25:56