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Titolo:
EFFECT OF WASABI ON ION SECRETION IN GUIN EA-PIG COLON
Autore:
NAKAYAMA H; SUZUKI T; SUZUKI Y;
Indirizzi:
SHIZUOKA IND RES INST SHIZUOKA PREFECTURE,FOOD & CHEM TECHNOL DIV,2078 MAKIGAOKA SHIZUOKA 421 JAPAN SHIZUOKA UNIV,SCH FOOD & NUTR SCI,PHYSIOL LAB SHIZUOKA 422 JAPAN
Titolo Testata:
Nippon Nogei Kagakukaishi
fascicolo: 4, volume: 72, anno: 1998,
pagine: 499 - 507
SICI:
0002-1407(1998)72:4<499:EOWOIS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
JPN
Soggetto:
INTESTINAL ELECTROLYTE TRANSPORT; DIARRHEAL DISEASE;
Keywords:
WASABI; USSING CHAMBER; SHORT-CIRCUIT CURRENT; CHLORIDE SECRETION; ANTIDIARRHOEA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
H. Nakayama et al., "EFFECT OF WASABI ON ION SECRETION IN GUIN EA-PIG COLON", Nippon Nogei Kagakukaishi, 72(4), 1998, pp. 499-507

Abstract

Chloride secretion in the intestine is important in many kinds of diarrhoea. We investigated the effects of wasabi (Wasabia japonica MATSUM) on chloride secretion in the distal colon of guinea pigs by measuring short-circuit current in Ussing chamber system. Water extracts of wasabi stems were treated with ether to remove lipid-soluble substances,and the resulting wasabi extract was studied. Wasabi extract on the serosal side of the colon reduced basal short-circuit current, The extract reduced the increases in short-circuit current caused by serotoninadded to the serosal side and by electrical field stimulation as well. In the presence of tetrodotoxin, wasabi extract reduced the increasein short-circuit current by bethanechol, but in the presence of both tetrodotoxin and indomethacin it did not affect this increase. In the presence of both tetrodotoxin and indomethacin, the effects of forskolin together with bethanechol were not affected by wasabi extract. These results indicate that wasabi extract can inhibit intestinal chloridesecretion by inhibiting submucosal secrete-motor nerves and prostaglandin synthesis. Wasabi extract may therefore have an antidiarrhoeal effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 14:59:20