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Titolo:
PROTEIN-KINASE-C REGULATORY DOMAIN SURROGATE PEPTIDES - EFFECTS OF METAL-IONS ON FOLDING, PHORBOL ESTER-BINDING, AND SELECTIVITY
Autore:
IRIE K; YANAI Y; OIE K; OHIGASHI H; WENDER PA;
Indirizzi:
KYOTO UNIV,FAC AGR,DEPT FOOD SCI & TECHNOL KYOTO 606 JAPAN STANFORD UNIV,DEPT CHEM STANFORD CA 94305
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 8, volume: 7, anno: 1997,
pagine: 965 - 970
SICI:
0960-894X(1997)7:8<965:PRDSP->2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYSTEINE-RICH DOMAIN; NEUROTRANSMITTER RELEASE; ZINC; BRAIN; IDENTIFICATION; PHOSPHOLIPIDS; ACTIVATION; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
K. Irie et al., "PROTEIN-KINASE-C REGULATORY DOMAIN SURROGATE PEPTIDES - EFFECTS OF METAL-IONS ON FOLDING, PHORBOL ESTER-BINDING, AND SELECTIVITY", Bioorganic & medicinal chemistry letters, 7(8), 1997, pp. 965-970

Abstract

The effects of zinc and other metal ions on the folding and phorbol ester-binding of protein kinase C (PKC) surrogates have been investigated using the second cysteine-rich domain model peptides of rat PKC gamma and mouse PKC eta (gamma-CRD2 and eta-CRD2). The results clearly show that zinc plays an important role in the folding and phorbol eater-binding of these PKC surrogates. In addition, while treatment of thesesurrogates with various divalent first row transition metal ions other than zinc resulted in binding at background levels, treatment with copper, silver, gold, or mercury completely abolished binding. It is especially noteworthy that cadmium treated eta-CRD2 showed a high level of binding while similarly treated gamma-CRD2 exhibited no binding. These results suggest that recent reports on the inhibition of conventional PKC by heavy metal ions could be explained by their effects on thefolding and binding of the CRD subunits. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:45:12