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Titolo:
EFFECTS OF CGS-21680, A SELECTIVE A(2A) ADENOSINE RECEPTOR AGONIST, ON CARDIAC-OUTPUT AND VASCULAR-RESISTANCE IN ACUTE HEART-FAILURE IN THEANESTHETIZED RAT
Autore:
NEKOOEIAN AA; TABRIZCHI R;
Indirizzi:
MEM UNIV NEWFOUNDLAND,HLTH SCI CTR,FAC MED ST JOHNS NF A1B 3V6 CANADA MEM UNIV NEWFOUNDLAND,HLTH SCI CTR,FAC MED ST JOHNS NF A1B 3V6 CANADA UNIV BRITISH COLUMBIA,FAC MED,HLTH SCI CTR 2176,DEPT PHARMACOL & THERAPEUT VANCOUVER BC V6T 1Z3 CANADA
Titolo Testata:
British Journal of Pharmacology
fascicolo: 8, volume: 123, anno: 1998,
pagine: 1666 - 1672
SICI:
0007-1188(1998)123:8<1666:EOCASA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING ENZYME-INHIBITOR; LEFT-VENTRICULAR FAILURE; CORONARY-ARTERY; INFARCT SIZE; RELAXATION; CGS-21680; PRESSURE; DOGS; CAPACITANCE; VASOPRESSIN;
Keywords:
A(2A) ADENOSINE RECEPTORS; ACUTE HEART FAILURE; VENOUS RESISTANCE; CARDIAC OUTPUT; ANESTHETIZED;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Nekooeian e R. Tabrizchi, "EFFECTS OF CGS-21680, A SELECTIVE A(2A) ADENOSINE RECEPTOR AGONIST, ON CARDIAC-OUTPUT AND VASCULAR-RESISTANCE IN ACUTE HEART-FAILURE IN THEANESTHETIZED RAT", British Journal of Pharmacology, 123(8), 1998, pp. 1666-1672

Abstract

1 The effects of CGS 21680, a selective A(2A) adenosine receptor agonist, on cardiac output, blood pressure, mean circulatory filling pressure (P-mcf), arterial and venous resistances, heart rate and left ventricular end-diastolic pressure were assessed in rats with acute heart failure by means of coronary artery occlusion. 2 Animals (n=6 in each group) were divided into five groups: group I, sham-operated vehicle-treated (0.9% saline; 0.018 mL min(-1)); groups II-V, subject to coronary artery occlusion and treated with vehicle (0.9% saline; 0.018 mL min(-1)) and CGS 21680 (0.1, 0.3 and 1.0 mu g kg(-1) min(-1)), respectively. Haemodynamic measurements were taken one hour after completion ofsurgery, ninety minutes after coronary artery occlusion (except in group I), and fifteen minutes after infusion of saline or CGS 21680. 3 Baseline haemodynamic measurements before occlusion were found not to differ significantly between the different groups of animals. However, after occlusion, cardiac output, rate of rise in left ventricular pressure (+dP/dt) and blood pressure were significantly reduced when compared to corresponding values in sham-operated animals. In addition, occlusion of the coronary artery resulted in a significant elevation in venous resistance, P-mcf and left ventricular end-diastolic pressure ascompared to corresponding values in sham-operated animals. 4 Infusionwith CGS 21680 at the highest dose significantly reduced blood pressure, arterial resistance and left ventricular end-diastolic pressure when compared to occluded vehicle-treated animals (group II). Administration of CGS 21680 at the highest dose also significantly increased cardiac output (28%) and heart rate (10%) in comparison to occluded vehicle-treated animals. In addition, the highest dose of CGS 21680 significantly reduced P-mcf (9%) and venous resistance (62%) in comparison tooccluded vehicle-treated animals. Administration of CGS 21680 did notsignificantly affect +dP/dt when compared to occluded vehicle-treatedanimals. 5 The results from the present investigation indicate that occlusion of the coronary artery in rats results in a state of heart failure characterized by reduced arterial pressure and cardiac output, and increased venous resistance, P-mcf and left ventricular end-diastolic pressure. Administration of CGS 21680 to animals with acute heart failure resulted in increased cardiac output which was due to reduced venous resistance, as well as increased heart rate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 18:33:20