Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PYY-PREFERRING RECEPTOR IN THE DORSAL VAGAL COMPLEX AND ITS INVOLVEMENT IN PYY STIMULATION OF GASTRIC-ACID SECRETION IN RATS
Autore:
YANG H; LI WP; REEVE JR; RIVIER J; TACHE Y;
Indirizzi:
W LOS ANGELES VET AFFAIRS MED CTR,CURE DIGEST DIS RES CTR,DEPT MED,11301 WILSHIRE BLVD LOS ANGELES CA 90073 UNIV CALIF LOS ANGELES,BRAIN RES INST LOS ANGELES CA 90073 SALK INST BIOL STUDIES,CLAYTON FDN LABS PEPTIDE BIOL LA JOLLA CA 92037
Titolo Testata:
British Journal of Pharmacology
fascicolo: 8, volume: 123, anno: 1998,
pagine: 1549 - 1554
SICI:
0007-1188(1998)123:8<1549:PRITDV>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIDE-YY RECEPTORS; PANCREATIC-POLYPEPTIDE RECEPTOR; NEUROPEPTIDE-Y; BINDING-SITES; FUNCTIONAL EXPRESSION; ANESTHETIZED RATS; BRAIN; IDENTIFICATION; CLONING; SUBTYPE;
Keywords:
NEUROPEPTIDE Y; PYY3-36; [PRO(34)]PYY; PANCREATIC POLYPEPTIDE; Y1 RECEPTOR AGONISTS; Y2 RECEPTOR AGONISTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
H. Yang et al., "PYY-PREFERRING RECEPTOR IN THE DORSAL VAGAL COMPLEX AND ITS INVOLVEMENT IN PYY STIMULATION OF GASTRIC-ACID SECRETION IN RATS", British Journal of Pharmacology, 123(8), 1998, pp. 1549-1554

Abstract

1 Microinjection of peptide YY (PYY, 7-46 pmol) into the dorsal vagalcomplex (DVC) stimulated gastric acid secretion in urethane-anaesthetized rats. Using a variety of neuropeptide Y (NPY) and PYY derivatives, we characterized the pharmacological profile of the receptor mediating the acid secretory response to PYY. 2 [Pro(34)]rat(r)/porcine(p)PYYand [Pro(34)]human(h)PYY (23-117 pmol), microinjected unilaterally into the DVC resulted in a similar maximal increase in net acid secretion reaching 68+/-11 and 89+/-31 mu mol 90 min(-1) respectively. 3 Rat/hNPY and pNPY (47 pmol) microinjected into the DVC induced a similar net gastric acid secretion (27+/-8 and 23+/-8 mu mol 90 min(-1) respectively) and a higher dose (116 pmol) tended to reduce the response. 4 Pancreatic polypeptide (PP, 4-46pmol), [Leu(31),Pro(34)]r/hNPY (47 and 117 pmol) and the Y2 selective agonists, hPYY(3-36), PNPY5-36 and pNPY(13-36) (25-168 pmol) microinjected into the DVC failed to influence basal gastric acid secretion. 5 The rank order of potency of PYY greaterthan or equal to[Pro(34)]r/pPYY=[Pro(34)]hPYY>r/hNPY=pNPY to stimulate gastric acid secretion upon injection into the DVC and the ineffectiveness of PP, [Leu(31),Pro(34)]NPY and C-terminal NPY/PYY fragments suggest that a PYY-preferring receptor subtype may be involved in mediating the stimulating effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:26:25