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Titolo:
PROLONGATION AND OPTIMIZATION OF DOPPLER ENHANCEMENT WITH A MICROBUBBLE US CONTRAST AGENT BY USING CONTINUOUS-INFUSION - PRELIMINARY EXPERIENCE
Autore:
ALBRECHT T; URBANK A; MAHLER M; BAUER A; DORE CJ; BLOMLEY MJK; COSGROVE DO; SCHLIEF R;
Indirizzi:
FREE UNIV BERLIN,KLINIKUM BENJAMIN FRANKLIN,DEPT RADIOL D-12200 BERLIN GERMANY UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,SCH MED,HAMMERSMITH HOSP,DEPT IMAGING LONDON ENGLAND UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED,SCH MED,HAMMERSMITH HOSP,DEPT MED STAT & EVALUAT LONDON ENGLAND SCHERING AG,DEPT CLIN DEV DIAGNOST D-1000 BERLIN GERMANY
Titolo Testata:
Radiology
fascicolo: 2, volume: 207, anno: 1998,
pagine: 339 - 347
SICI:
0033-8419(1998)207:2<339:PAOODE>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Keywords:
ARTERIES, FEMORAL; ARTERIES, US; CAROTID ARTERIES, US; MICROBUBBLES; ULTRASOUND (US), CONTRAST MEDIA; ULTRASOUND (US), DOPPLER STUDIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
T. Albrecht et al., "PROLONGATION AND OPTIMIZATION OF DOPPLER ENHANCEMENT WITH A MICROBUBBLE US CONTRAST AGENT BY USING CONTINUOUS-INFUSION - PRELIMINARY EXPERIENCE", Radiology, 207(2), 1998, pp. 339-347

Abstract

PURPOSE: To investigate whether continuous infusion of echo-enhancingcontrast agent for up to 15 minutes can provide uniform and prolongedenhancement. MATERIALS AND METHODS: Six volunteers each received one bolus and three infusions of a microbubble contrast agent over 6-15 minutes at (a) a standard rate (mean, 2.08 mL/min), (b) a fast rate at twice the standard rate, and (c) a slow rate at half the standard rate. Spectral Doppler intensitometry of the femoral artery was performed for all infusions. Spectral Doppler ultrasound (US) scans of the femoral artery and color Doppler US scans of the carotid artery were subjectively assessed. RESULTS: All infusions provided-an equilibrium plateauof constant prolonged enhancement starting after 2 minutes and lasting until the end of the infusion. Enhancement at the plateau was +13 dB(slow rate), +17.1 dB (standard rate), and +18.3 dB (fast rate) compared with baseline. Saturation artifacts with infusions were markedly fewer than those with bolus injections. Dose effectiveness (duration ofenhancement that measured at least 7.5 dB per gram of contrast agent)was markedly improved with the infusions, from 0.8 min/g for the bolus to 2.6 min/g for the slow infusion. CONCLUSION: Continuous infusion of the microbubble contrast agent provided prolonged and uniform enhancement of Doppler signals and improved image quality by minimizing saturation artifacts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 06:21:56