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Titolo:
FUNCTION AND SPECIFICITY OF HUMAN NATURAL-KILLER-CELL RECEPTORS
Autore:
MORETTA A; PAROLINI S; CASTRICONI R; BOTTINO C; VITALE M; SIVORI S; MILLO R;
Indirizzi:
UNIV BRESCIA,DIPARTIMENTO SCI BIOMED & BIOTECNOL BRESCIA ITALY IST SCI STUDIO & CURA TUMORI GENOA ITALY CTR BIOTECNOL AVANZATE GENOA ITALY UNIV GENOA,IST ISTOL & EMBRIOL GEN GENOA ITALY
Titolo Testata:
European journal of immunogenetics
fascicolo: 6, volume: 24, anno: 1997,
pagine: 457 - 468
SICI:
0960-7420(1997)24:6<457:FASOHN>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-I MOLECULES; HLA-CLASS-I; MHC CLASS-I; TYROSINE-PHOSPHATASE 1C; INHIBITORY RECEPTOR; NK CLONES; MONOCLONAL-ANTIBODIES; CYTOLYTIC FUNCTION; MEMBRANE-PROTEINS; SURFACE MOLECULES;
Tipo documento:
Review
Natura:
Periodico
Citazioni:
81
Recensione:
Indirizzi per estratti:
Citazione:
A. Moretta et al., "FUNCTION AND SPECIFICITY OF HUMAN NATURAL-KILLER-CELL RECEPTORS", European journal of immunogenetics, 24(6), 1997, pp. 457-468

Abstract

In humans, natural killer lymphocytes express HLA class I-specific inhibitory receptors belonging to at least two different molecular families. The first is represented by members of the Ig superfamily that are involved in the recognition of different groups of HLA class I alleles, and the second is represented by a molecular complex formed by CD94 and NKG2A that displays a broad specificity for various class I molecules including the 'non-classical' HLA-G molecules. In addition to the inhibitory receptors, a series of activating receptors has been identified. Some display the same specificities as the corresponding inhibiting receptors and can be viewed as HLA class I-specific activating receptors. Another group of activating receptors appear to be involved in the cytolytic activity against HLA-'negative' target cells. These receptors are clearly non-MHC specific and, under physiological conditions, their function is suppressed by the HLA class I-specific inhibitory receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 04:49:24