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Titolo:
IMMUNOHISTOCHEMICAL STUDY OF DESMOSOMES IN ORAL SQUAMOUS-CELL CARCINOMA - CORRELATION WITH CYTOKERATIN AND E-CADHERIN STAINING, AND WITH TUMOR BEHAVIOR
Autore:
SHINOHARA M; HIRAKI A; IKEBE T; NAKAMURA S; KURAHARA SI; SHIRASUNA K; GARROD DR;
Indirizzi:
KYUSHU UNIV,FAC DENT,DEPT ORAL & MAXILLOFACIAL SURG 2,HIGASHI KU,3-1-1 MAIDASHI FUKUOKA 812 JAPAN UNIV MANCHESTER,SCH BIOL SCI MANCHESTER M13 9PL LANCS ENGLAND
Titolo Testata:
Journal of pathology
fascicolo: 4, volume: 184, anno: 1998,
pagine: 369 - 381
SICI:
0022-3417(1998)184:4<369:ISODIO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOPROTEIN-3 DESMOCOLLINS; MONOCLONAL-ANTIBODY; ADHESION MOLECULES; URINARY-BLADDER; DIFFERENTIATION; EXPRESSION; PLAKOGLOBIN; COMPONENTS; IDENTIFICATION; CLASSIFICATION;
Keywords:
DESMOSOMES; ORAL SQUAMOUS CELL CARCINOMA; CYTOKERATIN; E-CADHERIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
M. Shinohara et al., "IMMUNOHISTOCHEMICAL STUDY OF DESMOSOMES IN ORAL SQUAMOUS-CELL CARCINOMA - CORRELATION WITH CYTOKERATIN AND E-CADHERIN STAINING, AND WITH TUMOR BEHAVIOR", Journal of pathology, 184(4), 1998, pp. 369-381

Abstract

Reduction or loss of the intercellular junctions known as desmosomes may contribute to the invasive and metastatic behaviour of various carcinomas. Previous studies have shown that metastasis of oral squamous cell carcinomas of the head and neck correlates with a reduction in immunohistochemical staining for desmoplakin and desmoglein at the invasion front. The primary aim of the present study was to extend these observations to include a third component of desmosomes, the glycoprotein desmocollin. An additional aim was to determine whether the differentiation status of rumours is reflected in their staining for cytokeratins 1, 13, and 19, and, if so, whether these parameters correlate withdesmosomal staining and/or metastasis. The study included 54 primary rumours of which 28 showed lymph node metastases. The results of this investigation show that rumours can be divided into three groups according to whether they have lost staining for no, one or more than one desmosomal component. A statistically significant correlation was foundbetween the number of desmosomal components lost and metastasis. Tumours could also be divided into five groups according to their stainingfor different combinations of cytokeratins. Furthermore, differentiation status as indicated both histologically and by cytokeratin staining correlated with reduced desmosomal staining and metastasis, Tumours were also examined for intensity of staining for the adhesion moleculeE-cadherin, Reduction in E-cadherin staining was correlated with modeof invasion and with reduction in desmosomal staining, but not with poor differentiation as indicated by cytokeratin staining. The results of this extensive study reinforce the view that adhesive junctions andadhesion molecules contribute to the suppression of tumour invasion and metastasis. (C) 1998 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:32:29