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Titolo:
1-ALPHA,25-DIHYDROXYVITAMIN D-3 AND PHORBOL ESTER MEDIATE THE EXPRESSION OF ALKALINE-PHOSPHATASE IN NB4 ACUTE PROMYELOCYTIC LEUKEMIA-CELLS
Autore:
SONG XD; NORMAN AW;
Indirizzi:
UNIV CALIF RIVERSIDE,DEPT BIOCHEM RIVERSIDE CA 92521 UNIV CALIF RIVERSIDE,DEPT BIOCHEM RIVERSIDE CA 92521 UNIV CALIF RIVERSIDE,DIV BIOMED SCI RIVERSIDE CA 92521
Titolo Testata:
Leukemia research
fascicolo: 1, volume: 22, anno: 1998,
pagine: 69 - 76
SICI:
0145-2126(1998)22:1<69:1DAPEM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; RETINOIC ACID; NEUTROPHILIC GRANULOCYTES; MACROPHAGE DIFFERENTIATION; BONE-MARROW; LINE; GENE; MATURATION; INDUCTION; RECEPTOR;
Keywords:
1-ALPHA,25-DIHYDROXYVITAMIN D-3; ALKALINE PHOSPHATASE; PMA; PROMYELOCYTIC LEUKEMIA CELLS; NB4 CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
X.D. Song e A.W. Norman, "1-ALPHA,25-DIHYDROXYVITAMIN D-3 AND PHORBOL ESTER MEDIATE THE EXPRESSION OF ALKALINE-PHOSPHATASE IN NB4 ACUTE PROMYELOCYTIC LEUKEMIA-CELLS", Leukemia research, 22(1), 1998, pp. 69-76

Abstract

Both 1 alpha,25-dihydroxyvitamin D-3 [1 alpha,25(OH)(2)D-3] and phorbol 12-myristate 13-acetate [PMA] are cytodifferentiation agents regulating myeloid cell line differentiation along the monocyte/macrophage pathway. Alkaline phosphatase (ALP) activity has been reported to be absent or present at low levels in monocytes/macrophages. In the presentstudy, the acute promyelocytic leukemia cell line (NB4) was found to undergo monocyte/macrophage differentiation and strongly express ALP activity after exposure to the combination of 1 alpha,25(OH)(2)D-3 and PMA treatment. The ALP stimulation was both dose- and time-dependent with the ED50 doses for 1 alpha,25(OH)(2)D-3 and PMA at 2 x 10(-10) M and 4 x 10(-11) M, respectively. Assessment of the cell morphology via cell adherence, phagocytosis and ALP staining confirmed that NB4 cellstreated by 1 alpha,25(OH)(2)D-3 plus PMA showed macrophage characteristics, but were also strongly stained with ALP. The present study is the first report that NB4 cells express ALP activity as a consequence of combination treatment with 1 alpha,25(OH)(2)D-3 and PMA. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:08:01