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Titolo:
WHOLE-BLOOD VISCOSITY AND THE INSULIN-RESISTANCE SYNDROME
Autore:
HOIEGGEN A; FOSSUM E; MOAN A; ENGER E; KJELDSEN SE;
Indirizzi:
UNIV OSLO,ULLEVAAL HOSP,DEPT INTERNAL MED N-0407 OSLO NORWAY
Titolo Testata:
Journal of hypertension
fascicolo: 2, volume: 16, anno: 1998,
pagine: 203 - 210
SICI:
0263-6352(1998)16:2<203:WVATIS>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH FACTOR-I; ESSENTIAL-HYPERTENSION; SKELETAL-MUSCLE; YOUNG MEN; CARDIOVASCULAR REACTIVITY; SYMPATHETIC ACTIVITY; GLUCOSE-METABOLISM; REFLECTANCE METERS; DIABETES-MELLITUS; CIGARETTE-SMOKING;
Keywords:
WHOLE-BLOOD VISCOSITY; INSULIN RESISTANCE; HYPERTENSION; LIPOPROTEINS; HEMORHEOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
A. Hoieggen et al., "WHOLE-BLOOD VISCOSITY AND THE INSULIN-RESISTANCE SYNDROME", Journal of hypertension, 16(2), 1998, pp. 203-210

Abstract

Background In a previous study we found that elevated blood viscositywas linked to the insulin resistance syndrome, and we proposed that high blood viscosity may increase insulin resistance. That study was based on calculated viscosity. Objective To determine whether directly measured whole-blood viscosity was related to the insulin-resistance syndrome in the same way as calculated viscosity had been found to be. Methods Healthy young men were examined with the hyperinsulinemic isoglycemic glucose clamp technique, and we related insulin sensitivity (glucose disposal rate) to other metabolic parameters and to blood viscosity, We established a technique for direct measurement of whole-blood viscosity. Results There were statistically significant negative correlations between glucose disposal rate and whole-blood viscosity at lowand high shear rates (r = -0.41, P = 0.007 for both, n = 42), Whole-blood viscosity was correlated positively (n = 15) to serum triglyceride (r = 0.54, P = 0.04) and total cholesterol (r = 0.52, P = 0.05), andnegatively with high-density lipoprotein cholesterol (r = -0.53, P = 0.04) concentrations. Insulin sensitivity index was correlated positively to high-density lipoprotein cholesterol (r = 0.54, P = 0.04) and negatively to serum triglyceride (r = -0.69, P = 0.005) and to total cholesterol (r = -0.81, P = 0.0003) concentrations. Conclusions The present results demonstrate for the first time that there is a negative relationship between directly measured whole-blood viscosity and insulinsensitivity as a part of the insulin-resistance syndrome. Whole-bloodviscosity contributes to the total peripheral resistance, and these results support the hypothesis that insulin resistance has a hemodynamic basis. (C) 1998 Rapid Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:17:28