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Titolo:
EX-VIVO INHIBITORY EFFECT OF THE 5-HT UPTAKE BLOCKER CITALOPRAM ON 5-HT SYNTHESIS
Autore:
MORET C; BRILEY M;
Indirizzi:
CTR RECH PIERRE FABRE,17 AVE JEAN MOULIN F-81106 CASTRES FRANCE
Titolo Testata:
Journal of neural transmission
fascicolo: 2-3, volume: 104, anno: 1997,
pagine: 147 - 160
SICI:
0300-9564(1997)104:2-3<147:EIEOT5>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL RAPHE NEURONS; RAT-BRAIN; ANTIDEPRESSANT DRUGS; IN-VIVO; 5-HYDROXYTRYPTAMINE RELEASE; SEROTONIN AUTORECEPTOR; RECEPTORS; INVIVO; AGONISTS; MICRODIALYSIS;
Keywords:
5-HT; SYNTHESIS; 5-HTP; UPTAKE; 5-HT RECEPTORS; CITALOPRAM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
C. Moret e M. Briley, "EX-VIVO INHIBITORY EFFECT OF THE 5-HT UPTAKE BLOCKER CITALOPRAM ON 5-HT SYNTHESIS", Journal of neural transmission, 104(2-3), 1997, pp. 147-160

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) synthesis was determined in vivo by measuring the accumulation of 5-hydroxytryptophan (5-HTP) in rat frontal cortex after inhibition of aromatic amino acid decarboxylase by administration of m-hydroxybenzylhydrazine (NSD 1015) (100 mg/kg, i.p.). The selective 5-HT reuptake inhibitor, citalopram, the 5-HT1A agonists, (+/-)8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT), ipsapirone, gepirone and the 5-HT1A/B agonist, (4-methyl-1-piperazinyl-pyrolol[1,2-a]-quinoxaline (CGS 12066B), the 5-HT1A/B ligands and beta-adrenoceptor antagonists, (+/-)pindolol and (+/-)alprenolol, and the nonselective 5-HT ligands, m-chlorophenvlpiperazine (mCPP) and metergoline, all inhibited the synthesis of 5-HT. The 5-HT1A/5-HT2 antagonist, spiperone alone, had no effect on basal 5-HT synthesis, however it attenuated the effect of 8-OH-DPAT by 56% and CGS 12066B by 39% but only barely that of citalopram by 17%. The selective 5-HT1A antagonist, WAY 100635, which did not modify by itself 5-HT synthesis, had no effect oncitalopram-induced reduction of 5-HT synthesis. Neither the 5-HT2 agonist, (+/-)1-(2,5-dimethoxy-4-indophenyl)-2-aminopropane (DOI) nor the5-HT2 antagonist, ritanserin, had any effect on the synthesis of 5-HT. In addition, ritanserin did not modify the inhibitory effect of citalopram. Methiothepin was the only compound to increase 5-HT synthesis. These results suggest that the effect of citalopram on the synthesis of 5-HT is not mediated by 5-HT1A or 5-HT2 receptors and that other receptors may be involved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 02:47:45