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Titolo:
KATANIN, A MICROTUBULE-SEVERING PROTEIN, IS A NOVEL AAA ATPASE THAT TARGETS TO THE CENTROSOME USING A WD40-CONTAINING SUBUNIT
Autore:
HARTMAN JJ; MAHR J; MCNALLY K; OKAWA K; IWAMATSU A; THOMAS S; CHEESMAN S; HEUSER J; VALE RD; MCNALLY FJ;
Indirizzi:
UNIV CALIF SAN FRANCISCO,DEPT CELLULAR & MOL PHARMACOL SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT CELLULAR & MOL PHARMACOL SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,HOWARD HUGHES MED INST SAN FRANCISCO CA 94143 UNIV CALIF DAVIS,SECT MOL & CELLULAR BIOL DAVIS CA 95616 KIRIN BREWERY CO LTD,CENT LABS KEY TECHNOL,KANAZAWA KU KANAGAWA JAPAN WASHINGTON UNIV,SCH MED,DEPT CELL BIOL ST LOUIS MO 63110
Titolo Testata:
Cell
fascicolo: 2, volume: 93, anno: 1998,
pagine: 277 - 287
SICI:
0092-8674(1998)93:2<277:KAMPIA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVE FUSION PROTEIN; DYNAMIC INSTABILITY; GAMMA-TUBULIN; CAENORHABDITIS-ELEGANS; STABLE MICROTUBULES; CRYSTAL-STRUCTURE; ESCHERICHIA-COLI; MITOTIC SPINDLE; BETA-GAMMA; COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Hartman et al., "KATANIN, A MICROTUBULE-SEVERING PROTEIN, IS A NOVEL AAA ATPASE THAT TARGETS TO THE CENTROSOME USING A WD40-CONTAINING SUBUNIT", Cell, 93(2), 1998, pp. 277-287

Abstract

Microtubule disassembly at centrosomes is involved in mitotic spindlefunction. The microtubule-severing protein katanin, a heterodimer of 60 and 80 kDa subunits, was previously purified and shown to localize to centrosomes in vivo. Here we report the sequences and activities ofthe katanin subunits, p60 is a new member of the AAA family of ATPases, and we show that expressed p60 has microtubule-stimulated ATPase and microtubule-severing activities in the absence of p80. p80 is a novel protein containing WD40 repeats, which are frequently involved in protein-protein interactions. The p80 WD40 domain does not participate in p60 dimerization, but localizes to centrosomes in transfected mammalian cells. These results indicate katanin's activities are segregated into a subunit (p60) that possesses enzymatic activity and a subunit (p80) that targets the enzyme to the centrosome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 03:03:16