Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
REDUCTION OF ARYL-HYDROCARBON RECEPTOR-MEDIATED ACTIVITY OF POLYCHLORINATED BIPHENYL MIXTURES DUE TO ANAEROBIC MICROBIAL DECHLORINATION
Autore:
QUENSEN JF; MOUSA MA; BOYD SA; SANDERSON JT; FROESE KL; GIESY JP;
Indirizzi:
MICHIGAN STATE UNIV,DEPT CROP & SOIL SCI E LANSING MI 48824 MICHIGAN STATE UNIV,INST ENVIRONM TOXICOL E LANSING MI 48824 MICHIGAN STATE UNIV,DEPT FISHERIES & WILDLIFE,PESTICIDE RES CTR E LANSING MI 48824
Titolo Testata:
Environmental toxicology and chemistry
fascicolo: 5, volume: 17, anno: 1998,
pagine: 806 - 813
SICI:
0730-7268(1998)17:5<806:ROARAO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
AROMATIC-HYDROCARBONS; IN-VITRO; PCBS; SEDIMENTS; MICROORGANISMS; BIODEGRADATION; LUCIFERASE; TOXICITY;
Keywords:
POLYCHLORINATED BIPHENYLS; DECHLORINATION; ETHOXYRESORUFIN-O-DEETHYLASE; ARYLHYDROCARBON RECEPTOR; TOXIC EQUIVALENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Quensen et al., "REDUCTION OF ARYL-HYDROCARBON RECEPTOR-MEDIATED ACTIVITY OF POLYCHLORINATED BIPHENYL MIXTURES DUE TO ANAEROBIC MICROBIAL DECHLORINATION", Environmental toxicology and chemistry, 17(5), 1998, pp. 806-813

Abstract

Aroclors 1242 and 1254 were anaerobically dechlorinated by microorganisms eluted from polychlorinated biphenyl (PCB)-contaminated River Raisin (RR) and Silver Lake (SL) sediments. Dechlorination occurred primarily from the meta positions. H4IIE rat hepatoma cell bioassays for ethoxyresorufin-O-deethylase (EROD)induction potency, a measure of aryl hydrocarbon receptor-mediated toxic potential, revealed that the potencies of the Aroclors were considerably reduced after dechlorination. The decreases in EROD induction potencies were dependent on the extent of dechlorination of the non-ortho-substituted and mono-ortho-substituted PCBs. Calculated 2,3.7,8-tetrachlorodibenzo-p-dioxin (TCDD) equivalents (TEqs(calc)) for the PCB mixtures were 5.7, 0.08, and 0.05 pM TEq(calc)/mu mole of PCBs for non-, RR-, and SL-dechlorinated Aroclor 1242, and 7.8, 1.6, and 1.0 phl TEq(calc)/ mu mole of PCBs for non-, RR-, and SL-dechlorinated. Aroclor 1254, respectively. Correspondence between TEqs(assay) determined using the H4IIE bioassay and TEqs(calc) indicated that no unexpected synergistic interactions occurred among components of the dechlorinated mixtures. These results indicate that thedioxinlike toxicities of PCB mixtures are substantially reduced by microbial reductive dechlorination, and that a constant ratio of TEq to total PCBs cannot be assumed in risk assessments.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:33:35