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Titolo:
INFUSION OF THE SEROTONIN(1B) (5-HT1B) AGONIST CP-93,129 INTO THE PARABRACHIAL NUCLEUS POTENTLY AND SELECTIVELY REDUCES FOOD-INTAKE IN RATS
Autore:
LEE MD; ALOYO VJ; FLUHARTY SJ; SIMANSKY KJ;
Indirizzi:
ALLEGHENY UNIV HLTH SCI,MCP HAHNEMANN SCH MED,DEPT PHARMACOL,3200 HENRY AVE PHILADELPHIA PA 19129 ALLEGHENY UNIV HLTH SCI,MCP HAHNEMANN SCH MED,DEPT PHARMACOL PHILADELPHIA PA 19129 UNIV PENN,SCH MED,DEPT ANIM BIOL & PHARMACOL PHILADELPHIA PA 19104 UNIV PENN,SCH MED,INST NEUROL SCI PHILADELPHIA PA 19104 UNIV PENN,SCH VET MED,INST NEUROL SCI PHILADELPHIA PA 19104 UNIV PENN,SCH VET MED,DEPT ANIM BIOL & PHARMACOL PHILADELPHIA PA 19104
Titolo Testata:
Psychopharmacology
fascicolo: 3, volume: 136, anno: 1998,
pagine: 304 - 307
Fonte:
ISI
Lingua:
ENG
Soggetto:
D-FENFLURAMINE; BINDING-SITES; RECEPTORS; TFMPP; LOCALIZATION; HYPOPHAGIA; RU-24969; ANOREXIA;
Keywords:
CP-93,129; SEROTONIN; 5-HT1B RECEPTOR; PARABRACHIAL NUCLEUS; PARAVENTRICULAR NUCLEUS; FEEDING; SATIETY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
M.D. Lee et al., "INFUSION OF THE SEROTONIN(1B) (5-HT1B) AGONIST CP-93,129 INTO THE PARABRACHIAL NUCLEUS POTENTLY AND SELECTIVELY REDUCES FOOD-INTAKE IN RATS", Psychopharmacology, 136(3), 1998, pp. 304-307

Abstract

Unilateral infusion of the selective 5-HT1B agonist, CP-93,129 (3-(1,2, 5, 6,-tetrahydropyrid-4-yl) pyrrolo[3,2-b]pyrid-5-one) into the parabrachial nucleus (PBN) of the pens reduced food consumption by rats. The hypophagia was dose-related (ED50 approximate to 1 nmol) and associated with fewer observations of feeding and more periods of inactivity. Water intake, grooming and exploratory activity were unaffected. CP-93.129 also decreased food intake when injected into the hypothalamic paraventricular nucleus, but this action was 50-fold less potent than administration into the PBN. Autoradiography demonstrated 5-HT1B sites in the PBN: this binding was displaced by CP-93,129. The results implicate parabrachial 5-HT1B receptors in mediating serotonergic enhancement of satiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:27:44