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Titolo:
TREATMENT OF CHRONIC HEPATITIS-C GENOTYPE-4 WITH ALPHA-INTERFERON IN SAUDI-ARABIA - A MULTICENTER STUDY
Autore:
ALFALEH FZ; SBEIH F; ALKARAWI M; ALMOFLEH IA; ALRASHED RS; AYOOLA A; ALAMRI S; MAYET I; ALHABBAL TM; ALOMAIR A; ALSOHAIBANI MO; ABDULLAH AO; MOHAMED SA; ELSHEIKH MAR;
Indirizzi:
KING SAUD UNIV,COLL MED,DEPT MED 38,POB 2925 RIYADH 11461 SAUDI ARABIA KING SAUD UNIV,COLL MED,DEPT PATHOL RIYADH 11461 SAUDI ARABIA KING FAHD NATL GUARD HOSP RIYADH SAUDI ARABIA RIYADH ARMED FORCES HOSP RIYADH SAUDI ARABIA
Titolo Testata:
Hepato-gastroenterology
fascicolo: 20, volume: 45, anno: 1998,
pagine: 488 - 491
SICI:
0172-6390(1998)45:20<488:TOCHGW>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRUS; THERAPY; RIBAVIRIN;
Keywords:
CHRONIC HEPATITIS C; ALPHA-INTERFERON; GENOTYPE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
F.Z. Alfaleh et al., "TREATMENT OF CHRONIC HEPATITIS-C GENOTYPE-4 WITH ALPHA-INTERFERON IN SAUDI-ARABIA - A MULTICENTER STUDY", Hepato-gastroenterology, 45(20), 1998, pp. 488-491

Abstract

BACKGROUND/AIM: Several studies have indicated that there are certainpredictive factors (gender, duration of infection with HCV, cirrhosisand genotype of HCV) of a better response with a-interferon treatmentin patients with chronic hepatitis C. The aim of this study was to evaluate these factors in Saudis and other Arab nationals with chronic hepatitis C - genotype 4 - undergoing alpha-interferon treatment. METHODOLOGY: A multicenter study was conducted between 1992 and 1994 on 80 consecutive patients who were prospectively recruited and randomized in treatment and control groups. RESULTS: The results of this multicenter study indicated a low response rate to a-interferon with an overallresponse rate of 43%, of which 28% was complete. The sustained response was only 16%. Among the reasons for this low response in our study are the high percentage of patients with cirrhosis and the long infection interval, as about 80% of our HCV cases were community-acquired, CONCLUSION: Liver cirrhosis was found to be the main predetermining factor for response to interferon treatment. Genotype 4 was not a contributing factor to the difference in response rate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 07:40:33