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Titolo:
EXPRESSION OF HSP-70 AS A POTENTIAL PROGNOSTIC MARKER FOR ACUTE REJECTION IN HUMAN LIVER-TRANSPLANTATION
Autore:
FLOHE S; SPEIDEL N; FLACH R; LANGE R; ERHARD J; SCHADE FU;
Indirizzi:
UNIV ESSEN GESAMTHSCH KLINIKUM,CLIN RES GRP SHOCK & MOF,HUFELANDSTR 55 D-45122 ESSEN GERMANY UNIV ESSEN GESAMTHSCH KLINIKUM,CLIN RES GRP SHOCK & MOF D-45122 ESSENGERMANY
Titolo Testata:
Transplant international
fascicolo: 2, volume: 11, anno: 1998,
pagine: 89 - 94
SICI:
0934-0874(1998)11:2<89:EOHAAP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC ISCHEMIA-REPERFUSION; TUMOR-NECROSIS-FACTOR; HEAT-SHOCK PROTEIN; MESSENGER-RNA; RAT HEARTS; INTERLEUKIN-6; INDUCTION; INJURY; RESISTANCE; STRESS;
Keywords:
HEAT SHOCK PROTEIN 70, ACUTE REJECTION, LIVER TRANSPLANTATION; REJECTION, ACUTE; COLD PRESERVATION; PCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
S. Flohe et al., "EXPRESSION OF HSP-70 AS A POTENTIAL PROGNOSTIC MARKER FOR ACUTE REJECTION IN HUMAN LIVER-TRANSPLANTATION", Transplant international, 11(2), 1998, pp. 89-94

Abstract

In experimental models, the synthesis of heat shock protein 70 (HSP 70) has been recognized as an intracellular response to ischemia and reperfusion, insults inherent to transplantation. In this study, the HSPresponse in early stages of human liver transplantation was investigated. HSP 70 mRNA expression was detected by means of reverse transcriptase (RT)-PCR in liver biopsies (n = 28) and in cells obtained from the organ perfusate (n = 14) following cold preservation. The expressionof HSP 70 differed substantially between individuals. Retrospective analysis revealed a close correlation of the amount of HSP 70 mRNA in perfusate cells and biopsies with the onset of organ dysfunction due toearly graft rejection. Patients with early graft rejection had a significantly lower amount of HSP 70 mRNA than patients without rejection. These results suggest a protective role of HSP 70 expression. Low levels of HSP 70 may, therefore, represent a prognostic marker for early graft rejection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 04:05:25