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Titolo:
GROWTH-HORMONE SECRETION DURING SLEEP IN MALE DEPRESSED-PATIENTS
Autore:
SAKKAS PN; SOLDATOS CR; BERGIANNAKI JD; PAPARRIGOPOULOS TJ; STEFANIS CN;
Indirizzi:
EGINIT HOSP,DEPT PSYCHIAT,74 VAS SOFIAS AVE ATHENS 11528 GREECE UNIV ATHENS,DEPT PSYCHIAT GR-10679 ATHENS GREECE
Titolo Testata:
Progress in neuro-psychopharmacology & biological psychiatry
fascicolo: 3, volume: 22, anno: 1998,
pagine: 467 - 483
SICI:
0278-5846(1998)22:3<467:GSDSIM>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOGENOUS-DEPRESSION; PSYCHIATRIC-PATIENTS; AFFECTIVE-ILLNESS; EEG; CLONIDINE; PROFILES; CORTISOL; 24-HOUR; DRUGS;
Keywords:
DEPRESSION; GROWTH HORMONE; SLEEP; SLOW WAVE SLEEP;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
P.N. Sakkas et al., "GROWTH-HORMONE SECRETION DURING SLEEP IN MALE DEPRESSED-PATIENTS", Progress in neuro-psychopharmacology & biological psychiatry, 22(3), 1998, pp. 467-483

Abstract

1. Growth hormone (GH) secretion during sleep was studied in ten malepatients with major depression according to DSM III and eight normal controls. 2. Samples were collected through a continuous blood withdrawal pump while sleep was recorded in the laboratory. 3. The results showed a marked decrease in the GH secretion mainly during the first three hours of sleep in depressed patients as compared to normal controls. DST and TRH tests were also administered to the same patients but nocorrelation was observed between a positive test and a blunted GH secretion, suggesting that the various neuroendocrinological disturbancesdo not coexist in all depressed patients. 4. This disturbance in GH secretion during sleep, along with reduced slow wave sleep (SWS), givessupport to the theory that GHRH is the common stimulus of SWS and GH release and that the ratio of GHRH and its counterpart CRH plays a major role in the pathophysiology of disturbed endocrine activity during sleep in depression.

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Documento generato il 05/07/20 alle ore 21:42:27