Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE ADRENERGIC MODULATION OF FIRINGS OF RESPIRATORY RHYTHM-GENERATINGNEURONS IN MEDULLA-SPINAL CORD PREPARATION FROM NEWBORN RAT
Autore:
ARATA A; ONIMARU H; HOMMA I;
Indirizzi:
SHOWA UNIV,SCH MED,DEPT PHYSIOL,SHINAGAWA KU,1-5-8 HATANODAI TOKYO 142 JAPAN SHOWA UNIV,SCH MED,DEPT PHYSIOL,SHINAGAWA KU TOKYO 142 JAPAN
Titolo Testata:
Experimental Brain Research
fascicolo: 4, volume: 119, anno: 1998,
pagine: 399 - 408
SICI:
0014-4819(1998)119:4<399:TAMOFO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROSTRAL VENTROLATERAL MEDULLA; SYMPATHETIC PREGANGLIONIC NEURONS; NORADRENERGIC MODULATION; GABAERGIC NEURONS; NEONATAL RAT; INVITRO; VASOMOTOR; NEUROTRANSMITTERS; EPINEPHRINE; MECHANISMS;
Keywords:
RESPIRATORY RHYTHM; ADRENALINE; BRAIN-STEM-SPINAL CORD PREPARATION; ROSTRAL VENTROLATERAL MEDULLA; NEONATAL RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
A. Arata et al., "THE ADRENERGIC MODULATION OF FIRINGS OF RESPIRATORY RHYTHM-GENERATINGNEURONS IN MEDULLA-SPINAL CORD PREPARATION FROM NEWBORN RAT", Experimental Brain Research, 119(4), 1998, pp. 399-408

Abstract

We analysed the modulation of respiratory neurons by adrenaline or noradrenaline (NA) in a newborn rat brainstem-spinal cord preparation. Adrenaline or NA caused a dose-dependent depression of the respiratory rhythm and induced C4 spinal tonic discharges. The inhibitory effect of adrenaline (ED50=0.5 mu M) on the respiratory rhythm was stronger than NA (ED50=5 mu M) The adrenaline respiratory rhythm depression was partially blocked by the alpha(1)-antagonist prazosin or by the alpha(2)-antagonist yohimbine. The C4 tonic discharge elicited by adrenaline was blocked by the alpha(1)-antagonist prazosin. The direct effects ofadrenaline on pre-inspiratory (Pre-I) neurons were examined in a synaptic blockade solution (low Ca), and fifty-six percent of Pre-I neurons were found to continue firing. In low-Ca solution, Pre-I neurons were excited (n=29 of 39) or depressed (n=5 of 39) by adrenaline, and excited by alpha(1)-agonist phenylephrine or depressed by alpha(2)-agonist clonidine. These results suggest that the respiratory rhythm depression under intact network conditions is mediated by some other inhibitory system. The inhibitory effect of adrenaline on the respiratory rhythm was partially blocked by the GABA(A)-antagonists bicuculline or picrotoxin, but not by the GABA(B)-antagonist phaclofen. The present results suggest that: (1) respiratory rhythm generation is more sensitive to adrenaline than NA through alpha-adrenergic action of adrenaline; (2) the activity of Pre-I neurons could be directly regulated by excitation via alpha(1)-receptors and inhibition via alpha(2)-receptors; and(3) the depression of the respiratory rhythm by adrenaline is partly mediated by GABA(A)ergic neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 04:36:56