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Titolo:
MUTUAL DEPENDENCE OF JUN-N-TERMINAL KINASE AND PROTEIN-KINASE-C ON THE ONCOGENIC RAS-P21 PROTEIN-INDUCED MITOGENIC SIGNALING PATHWAY
Autore:
CHUNG D; VILLAFANIA A; ANWAR K; AMAR S; RIJHWANI K; KUNG HF; ADLER V; RONAI Z; BRANDTRAUF P; YAMAIZUMI Z; PINCUS MR;
Indirizzi:
VET AFFAIRS MED CTR,DEPT PATHOL & LAB MED,800 POLY PL BROOKLYN NY 11209 VET AFFAIRS MED CTR,DEPT PATHOL & LAB MED BROOKLYN NY 11209 LONG ISL UNIV,DEPT CHEM BROOKLYN NY 00000 LONG ISL UNIV,DEPT BIOL BROOKLYN NY 00000 SUNY HLTH SCI CTR,DEPT PATHOL BROOKLYN NY 11203 NCI,LAB BIOCHEM PHYSIOL,FREDERICK CANC RES FACIL FREDERICK MD 21702 CUNY,MT SINAI MED CTR,RUTTENBERG CANC CTR NEW YORK NY 10029 COLUMBIA UNIV,SCH PUBL HLTH,DIV ENVIRONM SCI NEW YORK NY 10032 NATL CANC INST TOKYO JAPAN
Titolo Testata:
Medical science research
fascicolo: 3, volume: 26, anno: 1998,
pagine: 147 - 150
SICI:
0269-8951(1998)26:3<147:MDOJKA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
OOCYTE MATURATION; RAS PROTEINS; ACTIVATION; INDUCTION;
Keywords:
ONCOGENIC P21 PROTEIN; JUN KINASE (JNK) AND JUN PROTEINS; PROTEIN KINASE C (PKC); OOCYTE MATURATION; PKC INHIBITOR; JNK INHIBITORY PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
D. Chung et al., "MUTUAL DEPENDENCE OF JUN-N-TERMINAL KINASE AND PROTEIN-KINASE-C ON THE ONCOGENIC RAS-P21 PROTEIN-INDUCED MITOGENIC SIGNALING PATHWAY", Medical science research, 26(3), 1998, pp. 147-150

Abstract

We have previously presented evidence that there is a distinct oncogenic ras-p21 protein mitogenic signal transduction pathway causing maturation of oocytes. This pathway involves a direct interaction between p21 and jun-N terminal kinase (JNK) and its target, jun protein and activation of protein kinase C (PKC). The question arises as to the relationship between JNK and PKC on the oncogenic ras-p21 signal transduction pathway. We have now found that a selective inhibitor of PKC, CGP 41 251, blocks JNK-induced oocyte maturation and that a newly isolatedJNK inhibitory protein of Mr 26 kDa blocks PKC-induced oocyte maturation. This reciprocal inhibition of JNK by a PKC inhibitor and PKC by aJNK inhibitor suggests that each protein requires the activation of the other protein. A possible explanation of the mutual activation requirement is that both proteins activate jun. Phosphorylation of jun by one protein may facilitate phosphorylation by the other protein. That jun is critical on the oncogenic ras pathway is supported by the finding that a dominant negative mutant of jun blocks ras-p21 -induced oocyte maturation in a specific manner. (C) 1998 Chapman & Hall Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:24:27