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Titolo:
PHOSPHOLIPID BREAKDOWN AND CHOLINE RELEASE UNDER HYPOXIC CONDITIONS -INHIBITION BY BILOBALIDE, A CONSTITUENT OF GINKGO-BILOBA
Autore:
KLEIN J; CHATTERJEE SS; LOFFELHOLZ K;
Indirizzi:
UNIV MAINZ,DEPT PHARMACOL,OBERE ZAHLBACHER STR 67 D-55101 MAINZ GERMANY DR WILLMAR SCHWABE ARZNEIMITTEL,PHARMACOL SECT D-76227 KARLSRUHE GERMANY
Titolo Testata:
Brain research
fascicolo: 2, volume: 755, anno: 1997,
pagine: 347 - 350
SICI:
0006-8993(1997)755:2<347:PBACRU>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN ENERGY-METABOLISM; RAT-BRAIN; CEREBRAL-ISCHEMIA; EXTRACT; ACETYLCHOLINE; ACTIVATION; TISSUE; OUTPUT; CELLS; A(2);
Keywords:
CHOLINE; HIPPOCAMPAL SLICE; HYPOXIA; BILOBALIDE; GINKGO BILOBA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
J. Klein et al., "PHOSPHOLIPID BREAKDOWN AND CHOLINE RELEASE UNDER HYPOXIC CONDITIONS -INHIBITION BY BILOBALIDE, A CONSTITUENT OF GINKGO-BILOBA", Brain research, 755(2), 1997, pp. 347-350

Abstract

A marked increase of choline release from rat hippocampal slices was observed when the slices were superfused with oxygen-free buffer, indicating hypoxia-induced hydrolysis of choline-containing phospholipids. This increase of choline release was suppressed by bilohalide, an ingredient of Ginkgo biloba, but not by a mixture of ginkgolides. The EC50 value for bilobalide was 0.38 mu M. In ex vivo experiments, bilobalide also inhibited hypoxia-induced choline release when given p.o. in doses of 2-20 mg/kg 1 h prior to slice preparation. The half-maximum effect was observed with 6 mg/kg bilobalide. A similar effect was noted after p.o. administration of 200 mg/kg EGb 761, a ginkgo extract containing approximately 3% of bilobalide. We conclude that ginkgo extractscan suppress hypoxia-induced membrane breakdown in the brain, and that bilobalide is the active constituent for this effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 13:51:12