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Titolo:
SEROTONIN IN AGING, LATE-LIFE DEPRESSION, AND ALZHEIMERS-DISEASE - THE EMERGING ROLE OF FUNCTIONAL IMAGING
Autore:
MELTZER CC; SMITH G; DEKOSKY ST; POLLOCK BG; MATHIS CA; MOORE RY; KUPFER DJ; REYNOLDS CF;
Indirizzi:
UNIV PITTSBURGH,MED CTR,PET FACIL,B-938,200 LOTHROP ST PITTSBURGH PA 15213 UNIV PITTSBURGH,MED CTR,MHCRC LATE LIFE MOOD DISORDERS,ALZHEIMERS DISRES CTR PITTSBURGH PA 00000 UNIV PITTSBURGH,MED CTR,FUNCT BRAIN IMAGING RES PROGRAM PITTSBURGH PA00000
Titolo Testata:
Neuropsychopharmacology
fascicolo: 6, volume: 18, anno: 1998,
pagine: 407 - 430
SICI:
0893-133X(1998)18:6<407:SIALDA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL BLOOD-FLOW; TRITIATED IMIPRAMINE BINDING; LIVING HUMAN-BRAIN; 5-HT UPTAKE SITES; AGE-RELATED DIFFERENCES; H-3 PAROXETINE BINDING; HUMAN FRONTAL-CORTEX; SLOW-WAVE SLEEP; SUICIDE VICTIMS;
Keywords:
SEROTONIN; RECEPTORS; ALZHEIMERS DISEASE; DEPRESSION; AGING; EMISSION COMPUTED TOMOGRAPHY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
250
Recensione:
Indirizzi per estratti:
Citazione:
C.C. Meltzer et al., "SEROTONIN IN AGING, LATE-LIFE DEPRESSION, AND ALZHEIMERS-DISEASE - THE EMERGING ROLE OF FUNCTIONAL IMAGING", Neuropsychopharmacology, 18(6), 1998, pp. 407-430

Abstract

Serotonin (5-HT) neuron and neurotransmitter loss in normal aging andneuropsychiatric diseases of late life may contribute to behavioral changes commonly observed in the elderly population. Extensive evidenceimplicates a deficit in serotonergic neurotransmission in the development of major depression. It has been further suggested that the age-related changes in 5-HT neurons may predispose the elderly to develop depression. There is also increasing evidence that a combination of disturbances in cholinergic and serotonergic function may play a role in cognitive impairment in Alzheimer's disease (AD), with serotonergic dysfunction potentially responsible for a significant portion of the behavioral aspects of the disease. This implication of the 5-HT system inaging and age-related cognitive and mood disorders rests in large part on post mortem studies and animal models, which are limited in theircapacity to predict dynamic human biochemical-behavior relationships or to accurately model the living human brain. Initial applications offunctional brian imaging with positron emission tomography (PET) in the in vivo study of the brain in aging, depression, and dementia focused on characterizing alterations in physiological measurements of cerebral metabolism and perfusion. However, recent advances in PET radiochemistry, instrumentation, and image processing have paved the way for noninvasive means to test specific hypotheses regarding the direct involvement of 5-HT neurons in the behavioral features of aging and to define and monitor therapeutic regimens for neuropsychiatric conditions of late life. Coupling of clinical trials in well-characterized subject populations with PET imaging using ligands specific for 5-HT receptor subtypes and transporter proteins promises to increase our understanding of the role of the 5-HT system in affective and cognitive aspectsof treatment response. Longitudinal studies in aging late-life depression, and AD are also needed to evaluate the complex interplay betweenneurodegenerative processes and serotonergic neurotransmission. (C) 1998 American College of Neuropsychopharmacology. Published by ElsevierScience Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:41:17