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Titolo:
BONE-MINERAL CHANGES DURING PREGNANCY AND LACTATION - A LONGITUDINAL COHORT STUDY
Autore:
KOLTHOFF N; EIKEN P; KRISTENSEN B; NIELSEN SP;
Indirizzi:
CENT HOSP HILLEROD,DEPT CLIN PHYSIOL & NUCL MED DK-3400 HILLEROD DENMARK
Titolo Testata:
Clinical science
fascicolo: 4, volume: 94, anno: 1998,
pagine: 405 - 412
SICI:
0143-5221(1998)94:4<405:BCDPAL>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-METABOLISM; BIOCHEMICAL MARKERS; POSTPARTUM WOMEN; DENSITY; MASS; TURNOVER; HORMONE;
Keywords:
BONE DENSITY; BONE MASS; LACTATION; OSTEODENSITOMETRY; PHYSIOLOGY; PREGNANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
N. Kolthoff et al., "BONE-MINERAL CHANGES DURING PREGNANCY AND LACTATION - A LONGITUDINAL COHORT STUDY", Clinical science, 94(4), 1998, pp. 405-412

Abstract

1. The influence of pregnancy, lactation and weaning on bone mineral density in healthy women was investigated during a 2 year prospective study of 59 pregnant and lactating women from the 18th week of gestation. 2. Bone mineral density was measured by dual energy X-ray absorptiometry at the non-dominant radius ultra distally and more proximally in the 18th and 37th weeks of gestation, and 0, 3, 6, 12 and 18 months after delivery. Measurements of bone mineral density of the lumbar spine, the proximal femur and the whole body were performed at all dates after delivery. 3. Reappearance of menstruation after delivery averaged 6.1 months; mean lactating period was 8.7 months. During pregnancy and lactation bone mineral density tended to decrease, but different measuring sites show ed different patterns of bone mineral density changes. The reduction in the ultra distal radius during pregnancy amountedto 296, and no further changes were observed here during lactation. After delivery, reduction in mean bone mineral density was most pronounced in the spine (5.2% in 3 months), but the fall in bone mass tended to revert after resumption of menstruation. Bone mineral density was still reduced by 3.3% after 12 months in cr omen with menstruation resumption later than 8 months after delivery. No significant reduction was observed 18 months after delivery, No association with calcium intake, weight changes or initial bone mineral density was observed. High calcium intake did not protect against bone mineral loss in the spine and the femur. 4. Thus it can be concluded that bone loss during pregnancy and lactation took place mainly from the trabecular skeleton. Resumption of menstruation tended to result in a regain of bone mass towards baseline.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:54:01