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Titolo:
INFLUENCE OF CADMIUM INTOXICATION ON THROMBORESISTANCE OF VASCULAR ENDOTHELIUM IN RABBITS
Autore:
GRABOWSKAMASLANKA A; JANIK A; CHLAP Z; SZUPERSKAOCETKIEWICZ A; SLAWINSKI M; GRYLEWSKI RJ; KORBUT R;
Indirizzi:
JAGIELLONIAN UNIV,SCH MED,CHAIR PHARMACOL,16 GRZEGORZECKA STR PL-31531 KRAKOW POLAND JAGIELLONIAN UNIV,SCH MED,CHAIR PHARMACOL PL-31531 KRAKOW POLAND JAGIELLONIAN UNIV,SCH MED,DEPT EXPTL PATHOPHYSIOL,CHAIR PATHOPHYSIOL PL-31531 KRAKOW POLAND
Titolo Testata:
Journal of Physiology and Pharmacology
fascicolo: 1, volume: 49, anno: 1998,
pagine: 61 - 69
SICI:
0867-5910(1998)49:1<61:IOCIOT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Keywords:
VASCULAR THROMBORESISTANCE; CADMIUM INTOXICATION; PLATELET AGGREGATION; VASCULAR ENDOTHELIUM; PROSTACYCLIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
A. Grabowskamaslanka et al., "INFLUENCE OF CADMIUM INTOXICATION ON THROMBORESISTANCE OF VASCULAR ENDOTHELIUM IN RABBITS", Journal of Physiology and Pharmacology, 49(1), 1998, pp. 61-69

Abstract

Here, using our original technique for measuring of thrombogenesis onthe surface of rabbit aorta endothelium superfused with whole blood, we demonstrate that the thrombogenic property of endothelium is potentiated in the course of 3 months cadmium intoxication. The loss of endothelial thromboresistance is accompanied by suppressed generation of endogenous prostacyclin, leukopenia, increased platelet aggregability and by the presence of quasi-atherosclerotic, focal proliferative, glassy-protein lesions formed in aortic endothelium. We hypothesize that the final loss of vessel thromboresistance with all sequence of events that accompany cadmium intoxication, may result from the cadmium-induced inhibition of the generation of endothelial prostacyclin. However, the exact mechanism by which cadmium intoxication may affect the generation of prostacyclin and, then, functioning of blood platelets and vascular endothelium requires further investigations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 00:48:44