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Titolo:
CHARACTERIZATION OF AN HIV-1 P24(GAG) EPITOPE RECOGNIZED BY A CD8(-CELL CLONE() CYTOTOXIC T)
Autore:
BUSEYNE F; STEVANOVIC S; RAMMENSEE HG; RIVIERE Y;
Indirizzi:
INST PASTEUR,UNITE VIROL & IMMUNOL CELLULAIRE,URA CNRS 1157,28 RUE DRROUX F-75724 PARIS 15 FRANCE INST PASTEUR,UNITE VIROL & IMMUNOL CELLULAIRE,URA CNRS 1157 F-75724 PARIS 15 FRANCE INST ZELLBIOL,ABT IMMUNOL VERFUGUNGSGEBAUDE D-72176 TUBINGEN GERMANY
Titolo Testata:
Immunology letters
fascicolo: 3, volume: 55, anno: 1997,
pagine: 145 - 149
SICI:
0165-2478(1997)55:3<145:COAHPE>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HLA-C; HEAVY-CHAIN; EXPRESSION; POLYMORPHISM; LYMPHOCYTES; MOLECULES; PROTEIN; MOTIFS; ALLELE; LOCUS;
Keywords:
CYTOTOXIC T-LYMPHOCYTE; CTL EPITOPE; HLA-C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
F. Buseyne et al., "CHARACTERIZATION OF AN HIV-1 P24(GAG) EPITOPE RECOGNIZED BY A CD8(-CELL CLONE() CYTOTOXIC T)", Immunology letters, 55(3), 1997, pp. 145-149

Abstract

A CD8(+) cytotoxic T-cell clone that recognized HIV p24(gag) isolatedfrom an infected individual. The minimal epitope was localized to amino acids 308-316 (QASQEVKNW). Using allogeneic target cells, we found that lysis was restricted by the HLA-Cw0401 molecule. We observed thatCIR cells, that express the HLA-Cw0401 allele are able to present thepeptide to the cytotoxic clone, but with reduced efficiency. Other B-cell lines, that have been genotyped as HLA-Cw0401(+) were unable to present the peptide to the clone, suggesting the existence of other variants of HLA-Cw0401 or a loss of cell surface expression of this molecule. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:24:51