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Titolo:
PORTACAVAL ANASTOMOSIS RESULTS IN MORE WIDESPREAD ALTERATIONS OF CEREBRAL METABOLISM IN OLD VERSUS YOUNG-ADULT RATS - IMPLICATIONS FOR POST-SHUNT ENCEPHALOPATHY
Autore:
AUDET RM; BUTTERWORTH RF;
Indirizzi:
CHUM CAMPUS ST LUC,NEUROSCI RES UNIT,1058 ST DENIS ST MONTREAL PQ H2X3J4 CANADA UNIV MONTREAL,HOP ST LUC,NEUROSCI RES UNIT MONTREAL PQ CANADA
Titolo Testata:
Metabolic brain disease
fascicolo: 1, volume: 13, anno: 1998,
pagine: 69 - 78
SICI:
0885-7490(1998)13:1<69:PARIMW>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PORTAL-SYSTEMIC ENCEPHALOPATHY; INTRAHEPATIC PORTOSYSTEMIC SHUNT; MINIMAL HEPATIC-ENCEPHALOPATHY; GLUCOSE-UTILIZATION; LIVER-DISEASE; SYNAPTIC TRANSMISSION; SELECTIVE ALTERATIONS; AMMONIA METABOLISM; BINDING-SITES; H-3 PK-11195;
Keywords:
HEPATIC ENCEPHALOPATHY; PORTAL-SYSTEMIC ENCEPHALOPATHY; POST-SHUNT ENCEPHALOPATHY; PORTACAVAL ANASTOMOSIS; BRAIN GLUCOSE METABOLISM; AGE-RELATED CHANGES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Audet e R.F. Butterworth, "PORTACAVAL ANASTOMOSIS RESULTS IN MORE WIDESPREAD ALTERATIONS OF CEREBRAL METABOLISM IN OLD VERSUS YOUNG-ADULT RATS - IMPLICATIONS FOR POST-SHUNT ENCEPHALOPATHY", Metabolic brain disease, 13(1), 1998, pp. 69-78

Abstract

Treatment of portal hypertension by portal decompressive surgery or transjugular intrahepatic portosystemic stent shunt (TIPS) results in new or worsening episodes of portal-systemic encephalopathy, particularly in older patients. As part of a series of studies to elucidate the pathophysiologic mechanisms responsible for the age-related increased portal-systemic encephalopathy following shunt surgery, local cerebralglucose utilization, a measure of regional brain functional activity,was assessed using the C-14-2-deoxyglucose autoradiographic techniquein 2 month-old (young adult) and 24 month-old told adult) rats following end-to-side portacaval anastomosis. Cerebral glucose utilization was decreased by 22% (p<0.05) in frontal cortex of 2 month-old rats following portacaval anastomosis. More widespread alterations of glucose utilization, involving frontal and frontoparietal cortices, as well asthalamic structures were observed in the brains of 24 month-old rats following portacaval anastomosis despite blood ammonia concentrations of a comparable magnitude. Decreased cerebral glucose utilization in frontal and frontoparietal cortex of old adult rats following portacaval anastomosis probably results from decreased cerebral energy requirements as a consequence of neurotransmitter-related dysfunction. The greater susceptibility of aging brain to the deleterious effects of portacaval anastomosis is consistent with the higher incidence of encephalopathy in older cirrhotic patients following portacaval anastomosis or TIPS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:48:23