Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INFLUENCE OF BIOCHEMICAL-ALTERATIONS ON ARTERIAL STIFFNESS IN PATIENTS WITH END-STAGE RENAL-DISEASE
Autore:
BLACHER J; DEMUTH K; GUERIN AP; SAFAR ME; MOATTI N; LONDON GM;
Indirizzi:
HOP BROUSSAIS,SERV MED INTERNE,96 RUE DIDOT F-75674 PARIS 14 FRANCE INSERM,U337 PARIS FRANCE HOP BROUSSAIS,DEPT BIOCHEM F-75674 PARIS 14 FRANCE HOP MANHES,SERV NEPHROL HEMODIALYSE FLEURY MERGOIS FRANCE
Titolo Testata:
Arteriosclerosis, thrombosis, and vascular biology
fascicolo: 4, volume: 18, anno: 1998,
pagine: 535 - 541
SICI:
1079-5642(1998)18:4<535:IOBOAS>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA HOMOCYSTEINE; ENDOTHELIAL-CELLS; RADIAL ARTERY; SHEAR-STRESS; FAILURE; UREMIA; HYPERHOMOCYSTEINEMIA; ATHEROSCLEROSIS; HOMOCYST(E)INE; CALCIFICATION;
Keywords:
END-STAGE RENAL DISEASE; PULSE WAVE VELOCITY; HOMOCYSTEINE; ENDOTHELIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
J. Blacher et al., "INFLUENCE OF BIOCHEMICAL-ALTERATIONS ON ARTERIAL STIFFNESS IN PATIENTS WITH END-STAGE RENAL-DISEASE", Arteriosclerosis, thrombosis, and vascular biology, 18(4), 1998, pp. 535-541

Abstract

The incremental elastic modulus of the common carotid and radial arteries is increased in patients with end-stage renal disease (ESRD), independently of blood pressure, wall stress, and the presence of atherosclerotic alterations. Whether biochemical factors may be involved in the arterial changes and related to renal dysfunction remain largely ignored. To assess this question, we measured aortic (carotid-femoral), upper-limb (carotid-radial), and lower-limb (femoral-tibial) pulse wave velocity (PWV) in 74 ESRD patients undergoing hemodialysis in comparison with 57 control subjects similar in age, sex ratio, and mean blood pressure. We evaluated arterial blood pressure by sphygmomanometry, aortic calcifications and cardiac mass by echography, and routine biochemical parameters, total plasma homocysteine, and plasma endothelin levels by standard techniques. In the population of patients with ESRD,on the basis of multiple stepwise regression analysis, aortic PWV waspositively and independently correlated with systolic blood pressure (P<.0001), age (P<.0001), prevalence of aortic calcification (P=.0004), and the prevalence of diabetes mellitus (P=.0043). Upper-limb PWV was influenced exclusively by mean blood pressure (P<.0001). Lower-limb PWV was positively and independently correlated with plasma total homocysteine (P=.0004) and plasma endothelin (P=.0187) only. At any vascular site, PWV was not independently correlated with tobacco consumption; plasma levels of cholesterol, triglyceride, fibrinogen, or hemoglobin; body mass index; or the presence of bilateral nephrectomy, Finally,plasma homocysteine was independently correlated with cardiac mass (P=.0022). This study provides evidence that in ESRD patients, the stiffness of the arterial wall and cardiac mass are strongly influenced by biochemical factors related to the kidney alterations and are independent of age and blood pressure level. Increased plasma endothelin and homocysteine may be specifically involved in the vascular damage of lower limbs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:21:13