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Titolo:
A COMPARISON OF THE EFFECTS OF 2 ANABOLIC AGENTS (FLUORIDE AND PTH) ON ASH DENSITY AND BONE STRENGTH ASSESSED IN AN OSTEOPENIC RAT MODEL
Autore:
SOGAARD CH; MOSEKILDE L; THOMSEN JS; RICHARDS A; MCOSKER JE;
Indirizzi:
HERLUF TROLLES GADE 7B DK-8200 AARHUS N DENMARK UNIV AARHUS,INST ANAT,DEPT CELL BIOL AARHUS DENMARK UNIV AARHUS,ROYAL DENT COLL,DEPT ORAL ANAT DENT PATHOL & OPERAT DENT AARHUS DENMARK PROCTER & GAMBLE PHARMACEUT INC CINCINNATI OH 00000
Titolo Testata:
Bone
fascicolo: 5, volume: 20, anno: 1997,
pagine: 439 - 449
SICI:
8756-3282(1997)20:5<439:ACOTEO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGED OVARIECTOMIZED RATS; LONG-TERM EXERCISE; GROWTH-FACTOR-I; PARATHYROID-HORMONE; CORTICAL BONE; ANTIRESORPTIVE AGENTS; POSTMENOPAUSAL OSTEOPOROSIS; BIOMECHANICAL COMPETENCE; SODIUM-FLUORIDE; TRABECULAR BONE;
Keywords:
FLUORIDE; PTH; RAT; BONE STRENGTH; BONE QUALITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
C.H. Sogaard et al., "A COMPARISON OF THE EFFECTS OF 2 ANABOLIC AGENTS (FLUORIDE AND PTH) ON ASH DENSITY AND BONE STRENGTH ASSESSED IN AN OSTEOPENIC RAT MODEL", Bone, 20(5), 1997, pp. 439-449

Abstract

The aim of this investigation was to compare the effects of sodium fluoride (NaF) and parathyroid hormone (PTH) on ash density and strengthin an osteopenic rat model. The study comprised 66 female virgin ratsdivided into the following 11 groups, each comprising six animals: baseline controls; baseline ovariectomized (ovx); intact controls (5 and16 weeks), ovx controls (5 and 16 weeks); ovx-treated with PTH (0.02 mg/kg per day, 5 and 16 weeks); ovx treated with NaF (10 mg/kg per day, 5 and 16 weeks); ovx-treated with NaF (1.0 mg/kg per day, 16 weeks). Ovariectomy was performed at 12 weeks of age, 14 weeks prior to startof treatment. Ash density, bone fluoride content, and biomechanical analyses were performed on femoral cortical bone, the right femoral neck, and the sixth lumbar vertebral body. ovx had no effect on cortical bone, whereas the femoral neck displayed a significantly lower bone strength in ovx baseline animals compared with intact baseline rats (p <0.05). Vertebral ash density was found to be significantly decreased in ovx rats after 5 and 16 weeks (p < 0.05). Treatment with fluoride had little effect on the osteopenic rat skeleton. Cortical ash density was significantly lower than ovx and intact groups in the high-dose-treated rats after 5 (p < 0.01) but not after 16 weeks. High doses of fluoride for 16 weeks induced a significant increase in maximum load andnormalized strength in cortical bone when compared with intact animals (p < 0.05), but not at the other bone sites. Cortical bone strength was not different from the ovx animals at either timepoint. In fluoride-treated animals, femoral neck bone strength, vertebral body bone strength, bone quality, and ash density were found to be at about ovx levels and, in the vertebral body, significantly lower than intact animals (p < 0.05, p < 0.01). In contrast, treatment with PTH increased ash density, bone strength, and bone quality to above ovx levels (p < 0.01), and above the level of the intact animals also, although significant values were reached for cortical bone strength only (p < 0.01). Additionally, biomechanical competence and ash density measurements were significantly higher in PTH-treated rats compared with fluoride-treatedrats. In conclusion, this study has shown that PTH has a highly anabolic effect and is capable of effectively restoring ovx-induced loss ofbone mass and biomechanical competence. In addition, in this osteopenic rat model, PTH proved much more advantageous than treatment with fluoride, which failed to restore the ovx-induced loss of bone strength. (C) 1997 by Elsevier Science Inc.

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Documento generato il 30/11/20 alle ore 16:34:06