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Titolo:
EPIDEMIOLOGY OF INVASIVE PNEUMOCOCCAL INFECTIONS IN INFANTS AND YOUNG-CHILDREN IN METROPOLITAN SANTIAGO, CHILE, A NEWLY INDUSTRIALIZING COUNTRY
Autore:
LEVINE MM; LAGOS R; LEVINE OS; HEITMANN I; ENRIQUEZ N; PINTO ME; ALVAREZ AM; WU E; MAYORGA C; REYES A;
Indirizzi:
UNIV MARYLAND,SCH MED,CTR VACCINE DEV,685 W BALTIMORE ST BALTIMORE MD21201 HOSP SAN JUAN DIOS,INST SALUD PUBL SANTIAGO CHILE HOSP SAN JUAN DIOS,SERV SALUD METROPOLITANO NORTE SANTIAGO CHILE HOSP NINOS ROBERTO DEL RIO,CTR VACUNAS DESARROLLO CHILE SANTIAGO CHILE HOSP FELIX BULNES SANTIAGO CHILE CTR DIS CONTROL & PREVENT ATLANTA GA 00000
Titolo Testata:
The Pediatric infectious disease journal
fascicolo: 4, volume: 17, anno: 1998,
pagine: 287 - 293
SICI:
0891-3668(1998)17:4<287:EOIPII>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONJUGATE VACCINE; RESPIRATORY-TRACT; FEBRILE CHILDREN; UNITED-STATES; OTITIS-MEDIA; STREPTOCOCCUS-PNEUMONIAE; MATERNAL IMMUNIZATION; WEST-AFRICA; DISEASE; SEROTYPES;
Keywords:
STREPTOCOCCUS PNEUMONIAE; PNEUMOCOCCAL DISEASE; CHILE; PNEUMONIA; EMPYEMA; MENINGITIS; SEPTIC ARTHRITIS; PERITONITIS; CELLULITIS; EPIDEMIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
M.M. Levine et al., "EPIDEMIOLOGY OF INVASIVE PNEUMOCOCCAL INFECTIONS IN INFANTS AND YOUNG-CHILDREN IN METROPOLITAN SANTIAGO, CHILE, A NEWLY INDUSTRIALIZING COUNTRY", The Pediatric infectious disease journal, 17(4), 1998, pp. 287-293

Abstract

Aim. To study the epidemiology of invasive pneumococcal infections ininfants and young children in Santiago, Chile, as a representative pediatric population in a newly industrializing country where pneumococcal conjugate vaccines may be used in the future. Methods. A 5-year retrospective laboratory-based review (1989 to 1993) was followed by a S-year prospective laboratory and hospital surveillance study in two of the six health administrative areas of Santiago to detect all hospitalized cases of invasive pneumococcal disease (defined as Streptococcus pneumoniae isolated from blood, cerebrospinal fluid or another normally sterile site) among infants and children (0 to 23 months of age in the retrospective and 0 to 59 months of age in the prospective study). Results, During the B-year retrospective survey the incidence of invasive pneumococcal disease was 90.6 cases per 10(5) infants 0 to 11 months old and 18.5 cases per 10(5) toddlers 12 to 23 months old. Similar rates (60.2 per 10(5) infants and 18.1 per 10(5) toddlers) were recorded during the 3 years of prospective surveillance. Among the 110 casesin children 0 to 59 months of age detected during the 3-year prospective surveillance, 2 clinical forms, pneumonia and meningitis, accounted for 87.2% of all cases; 13 of the 49 pneumonia patients (26%) had empyema as a complication, Notably 40 of the 110 cases (36.4%) occurred before 6 months of age (63.4% of the 63 infant cases). Serotypes 1, 14, 5 and 6B were the most prevalent. Overall 76 and 69%, respectively, of S. pneumoniae isolates were antigenic types that would be covered by the 11- or 9-valent conjugate vaccines under development. Conclusions, Invasive pneumococcal infections in Santiago, Chile, exhibit an epidemiologic pattern intermediate between that of developing and industrialized countries, The high burden of disease in early infancy dictates that an accelerated immunization schedule (beginning in the perinatal period) or maternal immunization with pneumococcal vaccines should be explored.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 06:16:21