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Titolo:
THE IN-VIVO RELATIONSHIP BETWEEN BLOOD-FLOW, CONTRACTIONS, PH AND METABOLITES IN THE RAT UTERUS
Autore:
LARCOMBEMCDOUALL JB; HARRISON N; WRAY S;
Indirizzi:
UNIV LIVERPOOL,PHYSIOL LAB,CROWN ST LIVERPOOL L69 3BX MERSEYSIDE ENGLAND UNIV LIVERPOOL,PHYSIOL LAB LIVERPOOL L69 3BX MERSEYSIDE ENGLAND
Titolo Testata:
Pflugers Archiv
fascicolo: 6, volume: 435, anno: 1998,
pagine: 810 - 817
SICI:
0031-6768(1998)435:6<810:TIRBBC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR MAGNETIC-RESONANCE; INTRACELLULAR PH; SMOOTH-MUSCLE; UTERINE CONTRACTION; FORCE PRODUCTION; IN-VIVO; INHIBITION; HYPOXIA; ACIDIFICATION; PARTURITION;
Keywords:
UTERUS; NMR; CONTRACTION; SMOOTH MUSCLE; PH; BLOOD FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
J.B. Larcombemcdouall et al., "THE IN-VIVO RELATIONSHIP BETWEEN BLOOD-FLOW, CONTRACTIONS, PH AND METABOLITES IN THE RAT UTERUS", Pflugers Archiv, 435(6), 1998, pp. 810-817

Abstract

Little is known about the relationship between smooth muscle contractile activity and its blood supply. We have therefore investigated thisin the rat uterus, using laser-Doppler flow measurement and intra-uterine pressure recordings. We found an inverse linear relationship between flow and contractile activity. There was no evidence for a critical level of flow, above which function is maintained and below which itdeclines; even small reductions in blood flow decreased uterine force. Force was rapidly restored upon reperfusion. Reactive hyperaemia wasabsent from all but 6 of the 41 preparations studied. We used P-31 nuclear magnetic resonance (NMR) spectroscopy to measure concentrations of adenosine triphosphate (ATP), phosphocreatine (PCr), inorganic phosphate (Pi) and intracellular pH (pH(i)) simultaneously with force and flow. Reductions in flow were associated with significant reductions in [ATP], [PCr] and pH(i), and an increase in [Pi]. These changes were related to flow significantly and linearly and their effects on farce may be additive. These data show that uterine smooth muscle is closelydependent upon its blood supply for maintaining both normal force production and metabolite levels. Consequently, even small decrements in now may have deleterious functional effects.

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Documento generato il 30/11/20 alle ore 19:41:52