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Titolo:
LACTULOSE AND NEOMYCIN ATTENUATE LEUKOCYTE-ENDOTHELIAL CELL-ADHESION IN AN ANIMAL-MODEL OF INFLAMMATORY BOWEL-DISEASE
Autore:
ARNDT H; SCHOLMERICH J; PALITZSCH KD;
Indirizzi:
UNIV REGENSBURG,DEPT INTERNAL MED 1 D-93042 REGENSBURG GERMANY UNIV REGENSBURG,DEPT INTERNAL MED 1 D-93042 REGENSBURG GERMANY
Titolo Testata:
European journal of gastroenterology & hepatology
fascicolo: 4, volume: 10, anno: 1998,
pagine: 339 - 343
SICI:
0954-691X(1998)10:4<339:LANALC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC INTESTINAL INFLAMMATION; RAT; INDOMETHACIN; METRONIDAZOLE; ULCERATION; ADHERENCE; VENULES;
Keywords:
INDOMETHACIN; INFLAMMATORY BOWEL DISEASE; INTRAVITAL MICROSCOPY; LACTULOSE; NEOMYCIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
H. Arndt et al., "LACTULOSE AND NEOMYCIN ATTENUATE LEUKOCYTE-ENDOTHELIAL CELL-ADHESION IN AN ANIMAL-MODEL OF INFLAMMATORY BOWEL-DISEASE", European journal of gastroenterology & hepatology, 10(4), 1998, pp. 339-343

Abstract

Objective The role of intestinal flora in the pathogenesis of inflammatory bowel disease is under discussion. The objective of this study was to assess the effect of lactulose (Lac) and neomycin (Neo), both ofwhich are used clinically for changing or reducing intestinal flora, on leukocyte-endothelial cell interaction in an indomethacin (Indo)-induced long-lasting ileitis in Sprague-Dawley rats. Methods Two doses of Indo (7.5 mg/kg, s.c.) were given 24 h apart Animals were fed with standard rat chow for 10 days until 12 h prior to the experiment Solutions of Lac (1.0 mg/kg b,w,) or Neo (0.1 g/kg) were gavaged daily for 10 days between Indo administration and the experiment Ten mesenteric venules (30 mu m diameter) per animal (n = 5 per group) were observed using intravital microscopy, and the following parameters were monitored: number of adherent and emigrated leukocytes, leukocyte rolling velocity, erythrocyte velocity, venular blood Row, and shear rate. Macroscopically visible injury was scored 0 to 5, and faecal pH was measured in the distal 20 cm of ileum. Results Ten days after Indo treatment leukocyte adherence and emigration were increased (2.2-fold and 3.3-foldvs, control, respectively) while leukocyte rolling velocity and venular wall shear rate were reduced (both parameters to 81% of control). Lac and Neo attenuated microcirculatory parameters to a similar extent while macroscopic damage was prevented only by Neo but not by Lac. Theeffects of both substances were accompanied by a normalization of faecal pH to control level which had been lowered by Indo. Conclusion TheIndo-induced increase in leukocyte-endothelial cell interaction is blunted by Lac and Neo. At the same time the Indo-induced lowering of faecal pH is normalized by both substances. The reduction of macroscopicinjury by Neo but not by Lac in the chronic phase of Indo inflammation might be due to additional effects on other inflammatory cells such as macrophages, (C) 1998 Lippincott-Raven Publishers.

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Documento generato il 27/09/20 alle ore 00:57:31