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Titolo:
THE SEROTONERGIC AND NORADRENERGIC SYSTEMS OF THE HIPPOCAMPUS - THEIRINTERACTIONS AND THE EFFECTS OF ANTIDEPRESSANT TREATMENTS
Autore:
MONGEAU R; BLIER P; DEMONTIGNY C;
Indirizzi:
UNIV CALIF LOS ANGELES,DEPT PSYCHOL LOS ANGELES CA 90024 MCGILL UNIV,DEPT PSYCHIAT,NEUROBIOL PSYCHIAT UNIT MONTREAL PQ H3A 1A1CANADA
Titolo Testata:
Brain research reviews
fascicolo: 3, volume: 23, anno: 1997,
pagine: 145 - 195
SICI:
0165-0173(1997)23:3<145:TSANSO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL RAPHE NEURONS; LOCUS-COERULEUS NEURONS; LONG-TERM POTENTIATION; CENTRAL NERVOUS-SYSTEM; BETA-ADRENERGIC RECEPTORS; ANTI-DEPRESSANT TREATMENT; RAT-BRAIN CORTEX; REPEATED ELECTROCONVULSIVE SHOCK; MONOAMINE-OXIDASE INHIBITORS; STIMULATED ADENYLATE-CYCLASE;
Keywords:
SEROTONIN; NORADRENALINE; DEPRESSION; ANTIDEPRESSANT DRUG; ELECTROCONVULSIVE SHOCKS TREATMENT; LOCUS COERULEUS; RAPHE NUCLEUS; HIPPOCAMPAL FORMATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
497
Recensione:
Indirizzi per estratti:
Citazione:
R. Mongeau et al., "THE SEROTONERGIC AND NORADRENERGIC SYSTEMS OF THE HIPPOCAMPUS - THEIRINTERACTIONS AND THE EFFECTS OF ANTIDEPRESSANT TREATMENTS", Brain research reviews, 23(3), 1997, pp. 145-195

Abstract

Previous reviews have well illustrated how antidepressant treatments can differentially alter several neurotransmitter systems in various brain areas. This review focuses on the effects of distinct classes of antidepressant treatments on the serotonergic and the noradrenergic systems of the hippocampus, which is one of the brain limbic areas thought to be relevant in depression: it illustrates the complexity of action of these treatments in a single brain area. First, the basic elements (receptors, second messengers, ion channels,...) of the serotonergic and noradrenergic systems of the hippocampus are revisited and compared. Second, the extensive interactions occurring between the serotonergic and the noradrenergic systems of the brain are described. Finally, issues concerning the short- and long-term effects of antidepressanttreatments on these systems are broadly discussed. Although there aresome contradictions, the bulk of data suggests that antidepressant treatments work in the hippocampus by increasing and decreasing, respectively, serotonergic and noradrenergic neurotransmission. This hypothesis is discussed in the context of the purported function of the hippocampus in the formation of memory traces and emotion-related behaviors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 17:51:00