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Titolo:
DERIVATIZATION FOR ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY - 3 - ELECTROCHEMICALLY IONIZABLE DERIVATIVES
Autore:
VANBERKEL GJ; QUIRKE JME; TIGANI RA; DILLEY AS; COVEY TR;
Indirizzi:
OAK RIDGE NATL LAB,DIV CHEM & ANALYT SCI OAK RIDGE TN 37831 FLORIDA INT UNIV,DEPT CHEM MIAMI FL 33199 SCIEX MDS HLTH GRP CONCORD ON L4K 4V8 CANADA
Titolo Testata:
Analytical chemistry
fascicolo: 8, volume: 70, anno: 1998,
pagine: 1544 - 1554
SICI:
0003-2700(1998)70:8<1544:DFEM-3>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; FAST-ATOM-BOMBARDMENT; ASSISTED LASER DESORPTION/IONIZATION; ACID 2-(DIETHYLAMINO)ETHYL ESTER; SENSITIVE FERROCENE REAGENTS; CHARGE-TRANSFER COMPLEXATION; AMINO-ACIDS; CHEMICAL DERIVATIZATION; FULLERENE ANIONS; PEPTIDES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
66
Recensione:
Indirizzi per estratti:
Citazione:
G.J. Vanberkel et al., "DERIVATIZATION FOR ELECTROSPRAY-IONIZATION MASS-SPECTROMETRY - 3 - ELECTROCHEMICALLY IONIZABLE DERIVATIVES", Analytical chemistry, 70(8), 1998, pp. 1544-1554

Abstract

In this paper, the use of ferrocene-based ''electrochemically ionizable'' derivatives to enhance ES-MS analysis of simple alcohols, sterols, and phenols is discussed. These derivatives are designed to take advantage of the electrolysis process inherent to operation of the ES ionsource for selective ionization. Derivatization procedures, electrochemical character of the derivatives, and the ES-MS operational parameters necessary to maximize electrochemical ionization and to enhance gas-phase detection are presented with reference to ferrocenecarbamate ester derivatives of a variety of alcohol standards, as well as the ferroceneboronate derivative of the diol, pinacol. Tandem mass spectrometric analysis of the derivatives (precursor and product ion spectra) isshown to provide derivative confirmation, enhanced detection, and additional analyte structure information. The utility of this derivatization approach for the selective detection of alcohols in complicated mixtures is demonstrated using a saw palmetto (Serenoa repens) fruit extract known to contain a variety of alcohols at low levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:00:53