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Titolo:
MICE WITH AN INACTIVATION OF THE INDUCIBLE NITRIC-OXIDE SYNTHASE GENEARE SUSCEPTIBLE TO EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
Autore:
SAHRBACHER UC; LECHNER F; EUGSTER HP; FREI K; LASSMANN H; FONTANA A;
Indirizzi:
UNIV ZURICH HOSP,DEPT INTERNAL MED,CLIN IMMUNOL SECT,HALDELIWEG 4 CH-8044 ZURICH SWITZERLAND UNIV ZURICH HOSP,DEPT INTERNAL MED,CLIN IMMUNOL SECT CH-8044 ZURICH SWITZERLAND UNIV ZURICH HOSP,DEPT NEUROSURG CH-8044 ZURICH SWITZERLAND UNIV VIENNA,INST NEUROL EXPT NEUROPATHOL NEUROIMMUNOL & NEURO VIENNA AUSTRIA
Titolo Testata:
European Journal of Immunology
fascicolo: 4, volume: 28, anno: 1998,
pagine: 1332 - 1338
SICI:
0014-2980(1998)28:4<1332:MWAIOT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; T-CELLS; EXPRESSION; PATHOGENESIS; INHIBITORS; ARTHRITIS;
Keywords:
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PEROXYNITRITE; MYELIN OLIGODENDROCYTE GLYCOPROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
U.C. Sahrbacher et al., "MICE WITH AN INACTIVATION OF THE INDUCIBLE NITRIC-OXIDE SYNTHASE GENEARE SUSCEPTIBLE TO EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS", European Journal of Immunology, 28(4), 1998, pp. 1332-1338

Abstract

Nitric oxide (NO) generated by the inducible nitric oxide synthase (iNOS) has been implicated in the pathogenesis of experimental autoimmune encephalomyelitis (EAE). In this study mice genetically deficient for iNOS are shown to be susceptible to EAE induced by immunization withmyelin oligodendrocyte glycoprotein (MOG). In iNOS (-/-) mice the course of disease was earlier in onset and more aggressive compared to control animals. A disease-relevant compensatory up-regulation of neuronal (n)NOS and endothelial (e)NOS with increased production of NO in iNOS (-/-) mice is excluded by 1) the failure to detect increased nNOS and eNOS mRNA, 2) the absence of detection of nitrosylated tyrosine residues in EAE tissue indicating absence of NO-derived peroxynitrite, and 3) the lack of disease-preventing effects of N-G-nitro-L-arginine methyl ester. In conclusion, these results do not support the hypothesisthat NO is crucial for the development of EAE.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 01:42:14