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Titolo:
DIFFERENT EFFECTS OF OPIATE WITHDRAWAL ON DOPAMINE TURNOVER, UPTAKE, AND RELEASE IN THE STRIATUM AND NUCLEUS-ACCUMBENS
Autore:
GHOSH S; PATEL AH; COUSINS M; GRASING K;
Indirizzi:
UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,CLIN RES CTR,DEPT MED,DIV CLIN PHAMACOL NEW BRUNSWICK NJ 08903 UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,CLIN RES CTR,DEPT MED,DIV CLIN PHAMACOL NEW BRUNSWICK NJ 08903 UNIV CHICAGO,DEPT PHARMACOL & PHYSIOL SCI CHICAGO IL 60637
Titolo Testata:
Neurochemical research
fascicolo: 6, volume: 23, anno: 1998,
pagine: 875 - 885
SICI:
0364-3190(1998)23:6<875:DEOOWO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NALOXONE-PRECIPITATED WITHDRAWAL; BRAIN REWARD REGIONS; CHRONIC MORPHINE; EXTRACELLULAR DOPAMINE; ACETYLCHOLINE-RELEASE; RECEPTOR REGULATION; MESOLIMBIC SYSTEM; CEREBRAL DOPAMINE; RAT STRIATUM; NEURONS;
Keywords:
DOPAMINE; DOPAC; DRUG DEPENDENCE; MORPHINE; NUCLEUS ACCUMBENS; STRIATUM; SUBSTANTIA NIGRA; VENTRAL TEGMENTAL AREA; WITHDRAWAL SYNDROME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
S. Ghosh et al., "DIFFERENT EFFECTS OF OPIATE WITHDRAWAL ON DOPAMINE TURNOVER, UPTAKE, AND RELEASE IN THE STRIATUM AND NUCLEUS-ACCUMBENS", Neurochemical research, 23(6), 1998, pp. 875-885

Abstract

The purpose of these experiments was to further characterize changes in dopaminergic function that follow withdrawal from chronic opiate treatment. Withdrawal after treatment to a maximum dose of 120 mg/kg of morphine did not alter dopamine concentrations in the substantia nigra, ventral tegmental area, striatum, or nucleus accumbens; but did decrease concentrations of DOPAC and the ratio of DOPAC to dopamine in thelateral striatum and nucleus accumbens. Uptake of tritiated dopamine was diminished for withdrawn slices obtained from the striatum with noeffect observed for tissue from the nucleus accumbens. Deficits of invitro release of tritiated dopamine also occurred following withdrawal, with the nucleus accumbens being sensitive to dependence produced by a lower dose of morphine. In conclusion, opiate withdrawal produces a complex pattern of effects on dopaminergic function that is specificfor the striatum and nucleus accumbens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 14:01:36