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Titolo:
BIOLOGICAL BASIS OF OBSESSIVE-COMPULSIVE DISORDER
Autore:
NAVARRO JF; PUIGCERVER A;
Indirizzi:
FAC PSICOL,AREA PSICOBIOL,CAMPUS TEATINOS MALAGA 29071 SPAIN UNIV MALAGA E-29071 MALAGA SPAIN
Titolo Testata:
Psicologia conductual
fascicolo: 1, volume: 6, anno: 1998,
pagine: 79 - 101
SICI:
1132-9483(1998)6:1<79:BBOOD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
SPA
Soggetto:
CEREBRAL BLOOD-FLOW; GLUCOSE METABOLIC RATES; EMISSION COMPUTERIZED-TOMOGRAPHY; SACCADIC EYE-MOVEMENTS; MAGNETIC-RESONANCE; SMOOTH-PURSUIT; PSYCHIATRIC-DISORDERS; INTRANASAL OXYTOCIN; SYMPTOM PROVOCATION; CAUDATE-NUCLEUS;
Keywords:
OBSESSIVE-COMPULSIVE DISORDER (TOC); GENETIC STUDIES; PREFRONTAL MECHANISMS; CAUDATE; SEROTONIN; EYE MOVEMENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Navarro e A. Puigcerver, "BIOLOGICAL BASIS OF OBSESSIVE-COMPULSIVE DISORDER", Psicologia conductual, 6(1), 1998, pp. 79-101

Abstract

Obsessive-compulsive disorder (OCD) is a multidimensional and etiologically heterogenous condition. In this paper, we review genetic, neuroanatomical/neuroimaging and neurochemical studies which clearly indicate the existence of a biological substrate for this pathology. Although results are not entirely consistent, the majority of genetic studiessuggest that there is a familial determinant in OCD. On the other hand, recent structural and functional (CT, MRI, SPECT, PET, fMR) neuroimaging investigations have pointed to hyperactivity of prefrontal-striatal-thalamic circuitry in patients with OCD. Likewise, it is well established that drugs that produce a potent blockade of serotonin (5-HT) reuptake (SSRIs) have efficacy in the treatment of OCD, suggesting that serotonergic system could be implicated in this disorder. This ''5-HT hypothesis'' is also supported by numerous neurochemical/neuroendocrine studies. Finally, several reports demonstrating a dysfunction of eye movements in TOC are described.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 11:56:43