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Titolo:
MUCOUS-MEMBRANE PEMPHIGOID - A DUAL CIRCULATING ANTIBODY-RESPONSE WITH IGG AND IGA SIGNIFIES A MORE SEVERE AND PERSISTENT DISEASE
Autore:
SETTERFIELD J; SHIRLAW PJ; KERRMUIR M; NEILL S; BHOGAL BS; MORGAN P; TILLING K; CHALLACOMBE SJ; BLACK MM;
Indirizzi:
UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,ST THOMAS HOSP,ST JOHNS INST DERMATOL LONDON SE1 7EH ENGLAND UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,GUYS HOSP,DEPT ORAL MED &PATHOL LONDON SE1 7EH ENGLAND UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,ST THOMAS HOSP,DEPT OPHTHALMOL LONDON SE1 7EH ENGLAND UNITED MED & DENT SCH GUYS & ST THOMAS HOSP,ST THOMAS HOSP,DEPT PUBL HLTH MED LONDON SE1 7EH ENGLAND
Titolo Testata:
British journal of dermatology
fascicolo: 4, volume: 138, anno: 1998,
pagine: 602 - 610
SICI:
0007-0963(1998)138:4<602:MP-ADC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOELECTRON MICROSCOPY; ALTERNATIVE PATHWAY; BULLOUS DISEASES; COMPLEMENT; ANTIGEN; AUTOIMMUNE; IMMUNOFLUORESCENCE; ACTIVATION; TRANSPORT; DEFENSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
J. Setterfield et al., "MUCOUS-MEMBRANE PEMPHIGOID - A DUAL CIRCULATING ANTIBODY-RESPONSE WITH IGG AND IGA SIGNIFIES A MORE SEVERE AND PERSISTENT DISEASE", British journal of dermatology, 138(4), 1998, pp. 602-610

Abstract

Mucous membrane pemphigoid (MMP) is an autoimmune blistering disease frequently associated with scarring of involved clinical sites. At present, therapeutic intervention in the form of immunomodulating or immunosuppressive agents is often reserved until the onset of significant inflammation and/or early cicatrization. We have therefore studied theclinical and immunopathological findings in 67 patients with MMP in order to try to establish a reliable prognostic indicator by which patients at high risk may be identified early in the disease, Inclusion criteria were a predominantly mucosal disease and the detection of IgG and/or C3 anti-basement membrane zone (BMZ) immunoreactants using immunofluorescence techniques, Patients were allocated to three disease subgroups on the basis of the modality and duration of therapeutic intervention required to achieve effective control of disease. In addition, at presentation and at each follow-up visit, a clinical score for severity of involved clinical sites was awarded and serum collected for indirect immunofluorescence (IIF), A dual circulating anti-basement membrane zone (anti-BMZ) antibody response with IgG and IgA was significantly associated with a more severe and persistent disease profile (P < 0.001). The odds ratios for requiring systemic therapy were: 11.6 among patients in whom there was a clinical score greater than or equal to5 compared with a score < 5, and 31.3 and 66.9 among patients with IgG alone and both IgG and IgA, respectively compared with negative IIE The findings suggest that an assessment based upon a combination of site severity score and the presence of circulating IgG and IgA by IIF using 1 mol/L salt-split human skin substrate may be considered a useful prognostic indicator.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 22:26:29