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Titolo:
SUCCESSFUL RESECTION OF SIGMOID COLON-CANCER IN A PATIENT WITH FACTOR-XI DEFICIENCY
Autore:
UEN WC; CHOU YH; LIU CC; LIN SM; CHEN TJ;
Indirizzi:
SHIN KONG WU HO SU MEM HOSP,DEPT HEMATOL & ONCOL,95 WEN CHANG RD TAIPEI TAIWAN SHIN KONG WU HO SU MEM HOSP,DEPT SURG TAIPEI TAIWAN MACKAY MEM HOSP,CLIN LAB TAIPEI TAIWAN SHIN KONG WU HO SU MEM HOSP,DEPT PATHOL & LAB MED TAIPEI TAIWAN
Titolo Testata:
Journal of the Formosan Medical Association
fascicolo: 4, volume: 97, anno: 1998,
pagine: 283 - 285
SICI:
0929-6646(1998)97:4<283:SROSCI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
COAGULATION;
Keywords:
FACTOR XI DEFICIENCY; SIGMOID COLON CANCER; COAGULATION DISORDER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
W.C. Uen et al., "SUCCESSFUL RESECTION OF SIGMOID COLON-CANCER IN A PATIENT WITH FACTOR-XI DEFICIENCY", Journal of the Formosan Medical Association, 97(4), 1998, pp. 283-285

Abstract

A 42-year-old woman with sigmoid colon adenocarcinoma was found to have isolated prolonged activated partial thromboplastin time (aPTT 102.5 s, normal range 24-36 s) preoperatively. Her medical history included an episode of prolonged postdelivery uterine bleeding 16 years previously. A mixed aPTT test showed immediate correction of the prolonged aPTT, indicating a coagulation factor deficiency in the intrinsic pathway. Factor assays showed factor XI was below 1% of average normal value whereas factor VIII, IX, and MI activities were normal. Family screening revealed one sister among the three siblings also had isolated prolonged aPTT. The patient was transfused with four units (5mL/kg) of fresh frozen plasma the day before surgery, then with two units duringsurgery. The operation was uneventful with no bleeding problems. The patient recovered smoothly and is currently undergoing adjuvant chemotherapy. This is the first formal report of a patient with factor XI deficiency undergoing major surgery in Taiwan. Careful monitoring of aPTT, with fresh frozen plasma transfusion, when needed, may safely overcome bleeding problems during surgery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:34:22