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Titolo:
DIFFERENT PATTERNS OF NEURONAL INFECTION AFTER INTRACEREBRAL INJECTION OF 2 STRAINS OF PSEUDORABIES VIRUS
Autore:
CARD JP; LEVITT P; ENQUIST LW;
Indirizzi:
UNIV PITTSBURGH,DEPT NEUROSCI,446 CRAWFORD HALL PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT NEUROBIOL PITTSBURGH PA 15260 UNIV PITTSBURGH,DEPT PSYCHIAT PITTSBURGH PA 15260 PRINCETON UNIV,DEPT MOL BIOL PRINCETON NJ 08544
Titolo Testata:
Journal of virology
fascicolo: 5, volume: 72, anno: 1998,
pagine: 4434 - 4441
SICI:
0022-538X(1998)72:5<4434:DPONIA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HERPES-SIMPLEX VIRUS; AUJESZKYS-DISEASE VIRUS; CENTRAL-NERVOUS-SYSTEM; RAT VISUAL-SYSTEM; TRANSNEURONAL TRANSPORT; INTRANASAL INOCULATION; EFFERENT PROJECTIONS; PREFRONTAL CORTEX; PERIRHINAL CORTEX; GLYCOPROTEIN-GI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
J.P. Card et al., "DIFFERENT PATTERNS OF NEURONAL INFECTION AFTER INTRACEREBRAL INJECTION OF 2 STRAINS OF PSEUDORABIES VIRUS", Journal of virology, 72(5), 1998, pp. 4434-4441

Abstract

Pseudorabies virus (PRV), a swine neurotropic alphaherpesvirus, is known to invade the central nervous system (CNS) of a variety of animal species through peripherally projecting axons, replicate in the parentneurons, and then pass transsynaptically to infect other neurons of acircuit. Studies of the human pathogen herpes simplex virus type 1 have reported differences in the direction of transport of two strains of this virus after direct injection into the primate motor cortex. In the present study we examined the direction of transport of virulent and attenuated strains of PRV, utilizing injections into the rat prefrontal cortex to evaluate specific movement of virus through CNS circuitry, The data demonstrate strain-dependent patterns of infection consistent with bidirectional (anterograde and retrograde) transport of virulent virus and unidirectional (retrograde) transport of attenuated PRVfrom the site of injection. The distribution of infected neurons and the extent of transsynaptic passage also suggest that a release defectin the attenuated strain reduces the apparent rate of viral transportthrough neuronal circuitry, Finally, injection of different concentrations of virus influenced the onset of replication within a neural circuit. Taken together, these data suggest that viral envelope glycoproteins and virus concentration at the site of injection are important determinants of the rate and direction of viral transport through a multisynaptic circuit in the CNS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:46:53