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Titolo:
THE VESICULAR MONOAMINE TRANSPORTER - FROM CHROMAFFIN GRANULE TO BRAIN
Autore:
HENRY JP; SAGNE C; BEDET C; GASNIER B;
Indirizzi:
INST BIOL PHYSICOCHIM,CNRS,ERS 575,13 RUE PIERRE & MARIE CURIE F-75005 PARIS FRANCE
Titolo Testata:
Neurochemistry international
fascicolo: 3, volume: 32, anno: 1998,
pagine: 227 - 246
SICI:
0197-0186(1998)32:3<227:TVMT-F>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSE-CORE VESICLES; POSITRON EMISSION TOMOGRAPHY; SMALL SYNAPTIC VESICLES; BOVINE ADRENAL-MEDULLA; AMINE TRANSPORTER; DOPAMINE TRANSPORTER; CATECHOLAMINE TRANSPORTER; C-11 TETRABENAZINE; NEUROTRANSMITTER TRANSPORTERS; DIHYDROTETRABENAZINE-BINDING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
172
Recensione:
Indirizzi per estratti:
Citazione:
J.P. Henry et al., "THE VESICULAR MONOAMINE TRANSPORTER - FROM CHROMAFFIN GRANULE TO BRAIN", Neurochemistry international, 32(3), 1998, pp. 227-246

Abstract

All characterized monoaminergic cells utilize the same transport system for the vesicular accumulation of monoamines prior to their release. This system operates in neuronal (catecholaminergic, serotoninergic or histaminergic) as well as in endocrine or neuroendocrine cells. Forseveral decades, chromaffin granules from bovine adrenal medulla havebeen used as a model system, allowing progress in the understanding of the biophysics, the biochemistry and the pharmacology of the monoamine vesicular transporter. The transporters from rat, bovine and man have been cloned. Surprisingly, two genes encode different isoforms of the protein which are differentially expressed in monoaminergic systems. The conjunction of recombinant DNA techniques and expression in secretory or non-secretory cells with the large body of data obtained on the chromaffin granule transporter has allowed rapid progress in the study of the protein. But interestingly enough, this progress has open new possibilities in the study of biological problems, especially in the brain. The transporter is useful for the determination of the relationship between small and large dense core vesicles, for the understanding of the mechanism of drugs such as 1-methyl-4-phenylpyridinium (MPP), tetrabenazine or amphetamines, and as a marker in brain development. The possibility of regulations at the vesicular transporter level and of their effect on the quantum size has to be investigated. The vesicular monoamine transporter is also an important target for brain imaging. (C) 1998 Elsevier Science Ltd. All rights reserved.

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Documento generato il 08/04/20 alle ore 11:38:29