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Titolo:
VASCULAR ENDOTHELIAL GROWTH-PATTERN DURING DEMINERALIZED BONE-MATRIX INDUCED OSTEOGENESIS
Autore:
RABIE ABM;
Indirizzi:
UNIV HONG KONG,PRINCE PHILIP DENT HOSP,FAC DENT,34 HOSP RD HONG KONG HONG KONG
Titolo Testata:
Connective tissue research
fascicolo: 4, volume: 36, anno: 1997,
pagine: 337 -
SICI:
0300-8207(1997)36:4<337:VEGDDB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOCHONDRAL BONE; WOUND REPAIR; ANGIOGENESIS; MACROPHAGE; DEFECTS; CELLS;
Keywords:
ANGIOGENESIS; BONE INDUCTION; DEMINERALIZED BONE MATRIX; ULTRASTRUCTURE; CD31-ANTIGEN; FACTOR-VIII;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
A.B.M. Rabie, "VASCULAR ENDOTHELIAL GROWTH-PATTERN DURING DEMINERALIZED BONE-MATRIX INDUCED OSTEOGENESIS", Connective tissue research, 36(4), 1997, pp. 337

Abstract

The purpose of the current study was to determine the timely ingrowthof blood vessels associated with demineralized bone matrix (DBM) induced osteogenesis. Critical-size (10 x 5mm), full thickness bony defects in rabbit parietal bone were implanted with DBM. Histological and ultrastructural changes were examined 1, 2, 3, 4, 5, 6, 7 and 14 days later. Neovascularization was assessed by immunohistochemical staining for factor VIII antigen (marker for vascular endothelium) and also confirmed by staining using pan-endothelial antibody (CD31) (a marker for endothelium). Immunohistochemical evaluation revealed a positive staining for CD31 and Factor VIII expressed by endothelial cells by day 3 post grafting. By day 4, small blood vessels were first seen budding from host bed towards the grafted DBM. Ultrastructural identification ofcells in the early stages of healing revealed the presence of macrophages. The monocyte-derived macrophage appears to play a central role in the repair process using DBM. Results of this study demonstrated a rapid vascularization during the DBM induced osteogenesis. This rapid vascularization is vital to the healing and bone induction ability of the DBM.

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Documento generato il 02/12/20 alle ore 13:52:06