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Titolo:
ACTION OF POLYGODIAL, A SESQUITERPENE ISOLATED FROM DRYMIS-WINTERI, IN THE GUINEA-PIG ILEUM AND TRACHEA IN-VITRO
Autore:
ELSAYAH M; CECHINEL V; YUNES RA; PINHEIRO TR; CALIXTO JB;
Indirizzi:
UNIV FED SANTA CATARINA,DEPT PHARMACOL BR-88015240 FLORIANOPOLIS SC BRAZIL UNIV FED SANTA CATARINA,DEPT PHARMACOL BR-88015240 FLORIANOPOLIS SC BRAZIL UNIV VALE DO ITAJAI BR-88302202 ITAJAI SC BRAZIL UNIV FED SANTA CATARINA,DEPT CHEM BR-88015420 FLORIANOPOLIS SC BRAZIL
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 344, anno: 1998,
pagine: 215 - 221
SICI:
0014-2999(1998)344:2-3<215:AOPASI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA EXTRAVASATION; NK2 RECEPTORS; BRADYKININ; DISEASE; AIRWAYS; INFLAMMATION; ANAPHYLAXIS; TACHYKININS; OBSTRUCTION; MECHANISMS;
Keywords:
POLYGODIAL; ILEUM, GUINEA-PIG; TRACHEA, GUINEA-PIG; CONTRACTION; PROSTANOID; BRADYKININ; COMPOUND 48/70; OVALBUMIN; ASTHMA; ALLERGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M. Elsayah et al., "ACTION OF POLYGODIAL, A SESQUITERPENE ISOLATED FROM DRYMIS-WINTERI, IN THE GUINEA-PIG ILEUM AND TRACHEA IN-VITRO", European journal of pharmacology, 344(2-3), 1998, pp. 215-221

Abstract

This study describes the action of the sesquiterpene polygodial. the major constituent isolated from the bark of Drymis winteri in the guinea pig ileum and trachea in vitro. Polygodial (5 to 128 mu M), added for 20 min, did not affect the resting tone of the preparations, but caused graded inhibition, associated in some cases with rightward displacement of the acetycholine, histamine (1 nM to 10 mu M). bradykinin (0.1 nM to 1 mu M) and KCl (1 to 100 mM)-contraction response curves. When assessed in the guinea-pig trachea, polygodial (5 to 342 mu M) caused significant inhibition of bradykinin (10 pM to 1 mu M), 9.11-dideoxy-9 alpha,11 alpha-methano-epoxy prostaglandin F-2 alpha (0.1 to 1000 nM) and KCI (1 to 190 mM)-induced contractions, although the action against bradykinin was not concentration-dependent. Polygodial (5 to 80 mu M) caused a small but significant shift to the right of substance Pand also the selective agonist of tachykinin NK1 receptor [ beta-Ala(8)]neurokinin A-(4-10)-induced contractions in guinea pig trachea Thisaction of polygodial seems to be quite selective towards tachykinin NK2 receptors since up to 432 mu M, polygodial had no effect against contraction caused by tachykinin NK, receptor agonist. substance P methyl ester. When tested in the guinea-pig trachea from animals which had been actively sensitised to ovalbumin, polygodial (30 to 40 mu M) caused time and concentration-dependent inhibition of ovalbumin-mediated contraction. In addition, polygodial (85 to 342 mu M) inhibited contraction induced by compound-48/80 (1 to 1000 mu g/ml), in the guinea-pig trachea from non-sensitised animals. These findings and those from ourprevious study are consistent with the notion that the main sesquiterpene polygodial isolated from the bark of D. winteri is responsible for most, if not all, of the relevant pharmacological action reported previously for the extract of this plant. Thus, polygodial could be of potential value in the development of a new drug for the treatment of asthma. allergy and other inflammatory processes. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:29:24